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- W6228066 abstract "Publisher Summary This chapter discusses the intracellular delivery of cysteine. Intracellular cysteine is required for the synthesis of proteins, glutathione, and a number of other metabolites that are considered in this volume. The chapter discusses the administration of L-cysteine in experimental and therapeutic situations may be undesirable and that a means for delivering cysteine intracellularly would therefore be useful. An ideal intracellular delivery system for cysteine would consist of a derivative of cysteine, which is readily transported into cells and which after transport, is effectively converted to cysteine. It is important that the other product (or products) formed intracellularly in the release of cysteine from its transport vehicle be nontoxic and/or readily metabolizable. There are a number of ways in which cysteine might be delivered intracellularly. For example, various N-substituted cysteine derivatives including glutathione and other cysteine-containing peptides may be considered. N-acetyl-L-cysteine that is commonly used for the treatment of acetaminophen toxicity is apparently transported into cells. However, it is less effective than L-2-oxothiazolidine 4-carboxylate in increasing the glutathione levels in the livers of mice treated with acetaminophen. The chapter describes the administration of L-2-oxothiazolidine 4-carboxylate as an intracellular cysteine delivery system." @default.
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- W6228066 date "1987-01-01" @default.
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- W6228066 title "Intracellular delivery of cysteine" @default.
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- W6228066 doi "https://doi.org/10.1016/0076-6879(87)43059-0" @default.
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