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- W622902227 abstract "It has been revealed that many types of drugs interact with transporter proteins within an organism. Transporter proteins absorb or excrete materials, including drugs and nutrients, across the cell membrane. Some hydrophobic drugs are excreted from the cell as xenobiotics by ATP-binding cassette (ABC) transporters. However, solute carrier (SLC) transporters are tissue-specifically expressed and have substrate specificities. Thus, transporter-conscious drug design is an excellent method of delivering drugs to pharmaceutical target organs and provides advantages in absorption, distribution, excretion, and toxicity of drugs (ADMET) due to transport systems. In fact, based on this strategy, the bioavailability of prodrugs designed as peptide transporter 1 (PEPT1) substrates was better than that of the corresponding parent compounds due to the transport system in the small intestine. Furthermore, in central nervous system (CNS) drug developing, drug delivery into brain across the blood-brain barrier (BBB) is a serious problem. However, this problem can be also solved by the use of the transport systems at the BBB. Therefore, transporter-consciously designed drugs not only may effectively elicit activity but also may control adverse side effects caused by off-targets and drug-drug interactions and, consequently, may show good performance in clinical trials. In this review, I introduce possibilities and advantages of transporter-conscious drug designs." @default.
- W622902227 created "2016-06-24" @default.
- W622902227 creator A5073381113 @default.
- W622902227 date "2015-08-01" @default.
- W622902227 modified "2023-09-25" @default.
- W622902227 title "Intriguing possibilities and beneficial aspects of transporter-conscious drug design" @default.
- W622902227 cites W1964090448 @default.
- W622902227 cites W1966044988 @default.
- W622902227 cites W1970263371 @default.
- W622902227 cites W1970359870 @default.
- W622902227 cites W1973544766 @default.
- W622902227 cites W1975591425 @default.
- W622902227 cites W1976297946 @default.
- W622902227 cites W1976488832 @default.
- W622902227 cites W1980345475 @default.
- W622902227 cites W1981737096 @default.
- W622902227 cites W1983636667 @default.
- W622902227 cites W1983743185 @default.
- W622902227 cites W1985280643 @default.
- W622902227 cites W1989639080 @default.
- W622902227 cites W1990219735 @default.
- W622902227 cites W1991068811 @default.
- W622902227 cites W1993418630 @default.
- W622902227 cites W1994532346 @default.
- W622902227 cites W1995680035 @default.
- W622902227 cites W1996719014 @default.
- W622902227 cites W1997301724 @default.
- W622902227 cites W2000283182 @default.
- W622902227 cites W2001577492 @default.
- W622902227 cites W2006846454 @default.
- W622902227 cites W2007087134 @default.
- W622902227 cites W2009979602 @default.
- W622902227 cites W2011069477 @default.
- W622902227 cites W2018530596 @default.
- W622902227 cites W2018950212 @default.
- W622902227 cites W2020059317 @default.
- W622902227 cites W2021263341 @default.
- W622902227 cites W2023733050 @default.
- W622902227 cites W2027719768 @default.
- W622902227 cites W2037612386 @default.
- W622902227 cites W2041140779 @default.
- W622902227 cites W2043725363 @default.
- W622902227 cites W2048265770 @default.
- W622902227 cites W2049222379 @default.
- W622902227 cites W2049519918 @default.
- W622902227 cites W2052888437 @default.
- W622902227 cites W2053921790 @default.
- W622902227 cites W2058265224 @default.
- W622902227 cites W2058764673 @default.
- W622902227 cites W2059924500 @default.
- W622902227 cites W2061813490 @default.
- W622902227 cites W2064447442 @default.
- W622902227 cites W2068975795 @default.
- W622902227 cites W2070226037 @default.
- W622902227 cites W2070902035 @default.
- W622902227 cites W2075018939 @default.
- W622902227 cites W2077851143 @default.
- W622902227 cites W2079197876 @default.
- W622902227 cites W2083562382 @default.
- W622902227 cites W2084970293 @default.
- W622902227 cites W2092108048 @default.
- W622902227 cites W2096523918 @default.
- W622902227 cites W2099384461 @default.
- W622902227 cites W2100845862 @default.
- W622902227 cites W2102136861 @default.
- W622902227 cites W2107968554 @default.
- W622902227 cites W2112893277 @default.
- W622902227 cites W2117339170 @default.
- W622902227 cites W2119463988 @default.
- W622902227 cites W2147241123 @default.
- W622902227 cites W2155294600 @default.
- W622902227 cites W2161427390 @default.
- W622902227 cites W2164706557 @default.
- W622902227 cites W2170326611 @default.
- W622902227 cites W2170822335 @default.
- W622902227 cites W2173677143 @default.
- W622902227 cites W2314088626 @default.
- W622902227 cites W2314473516 @default.
- W622902227 cites W2315351629 @default.
- W622902227 cites W2319265080 @default.
- W622902227 cites W2319998195 @default.
- W622902227 cites W2320197732 @default.
- W622902227 cites W2326085958 @default.
- W622902227 cites W2329644198 @default.
- W622902227 cites W2333629601 @default.
- W622902227 cites W2614254245 @default.
- W622902227 doi "https://doi.org/10.1016/j.bmc.2015.06.022" @default.
- W622902227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26138194" @default.
- W622902227 hasPublicationYear "2015" @default.
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