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- W62353298 abstract "A transient decrease in the histochemically detectable zinc granules was observed in the β-cells of the rat 16–24 h after a peroral dose of 5 mg/kg of glibenclamide with complete restoration after 5–6 days. The aldehyde–fuchsinophil β-granules showed identical variations. The zinc in the α-cells was unaffected. Similar results were obtained with tolbutamide (200 mg/kg orally) though the restoration of zinc granules occurred somewhat more rapidly. A diabetogenic dose of alloxan evoked a marked and irreversible decrease of zinc in the β-cells, starting 4 h after an intravenous injection and being complete after 1–2 days. The aldehyde–fuchsin positive material remained longer in the dying β-cells than the zinc granules. Apart from a slight decrease after 4 h, the zinc in the α-cells was essentially unaffected by the alloxan administration." @default.
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- W62353298 date "1970-01-01" @default.
- W62353298 modified "2023-09-27" @default.
- W62353298 title "HISTOCHEMICAL EVIDENCE FOR A SULFONYLUREA EFFECT ON THE ZINC CONTENT OF THE PANCREATIC ISLETS" @default.
- W62353298 cites W2398691835 @default.
- W62353298 doi "https://doi.org/10.1016/b978-0-08-015844-0.50026-2" @default.
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