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- W623704908 abstract "Drug resistance in corneal herpes has been frequently reported, and the development of resistance to antimetabolites such as idoxuridine (IDU) and trifluorothymidine (TFT) has been shown with herpes simplex virus (HSV) grown in cell cultures. In this study the TFT sensitivity of corneal HSV 1 isolates was tested in human diploid fibroblast cell cultures. In 28 cases of dendritic keratitis treated topically with TFT, paired isolates revealed no significant change of TFT sensitivity during the course of treatment. Attempts to induce drug resistance by culturing HSV in the presence of TFT failed. Marked cytotoxicity of the drug was observed at concentrations only slightly above that of minimal antiviral activity in the culture system used." @default.
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- W623704908 date "1981-01-01" @default.
- W623704908 modified "2023-09-27" @default.
- W623704908 title "Trifluorthymidine Sensitivity of Ocular Herpes Simplex Virus Strains" @default.
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- W623704908 doi "https://doi.org/10.1007/978-3-642-80499-1_57" @default.
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