Matches in SemOpenAlex for { <https://semopenalex.org/work/W62371999> ?p ?o ?g. }
- W62371999 endingPage "2253" @default.
- W62371999 startingPage "2241" @default.
- W62371999 abstract "We previously showed that a mammary-specific dominant-negative p53 transgene (WAP-p53(172H)) could accelerate ErbB2-induced mammary tumorigenesis in mice, but was not tumorigenic on its own. To identify other genes that cooperate with WAP-p53(172H) in tumorigenesis, we performed mouse mammary tumor virus (MMTV) proviral mutagenesis. We derived F1, N2, and N4/N5 mice from p53(172H) transgenic FVB mice backcrossed onto MMTV+ C3H/He mice. Results show the latency of MMTV tumorigenesis is correlated with FVB contribution. F1 tumors had the shortest latency (217 days), had a higher rate of metastasis, and were less differentiated than the N2 and N4/N5 tumors. The latency was 269 days in N2 mice, and lengthened to 346 days in N4/N5 mice. p53(172H) significantly accelerated MMTV tumorigenesis only in N2 mice, indicating cooperativity between p53(172H) and MMTV in this cohort. To identify genes that may be causally involved in MMTV-induced mammary tumorigenesis, we identified 60 sites of proviral insertion in the N2 tumors. Among the insertions in p53(172H) transgenic tumors were 10 genes not previously found as sites of MMTV insertion including genes involved in signaling (Pdgfra, Pde1b, Cnk1), cell adhesion (Cd44), angiogenesis (Galgt1), and transcriptional regulation (Olig1, Olig2, and Uncx4.1). These may represent cellular functions that are likely not deregulated by mutation in p53." @default.
- W62371999 created "2016-06-24" @default.
- W62371999 creator A5005326043 @default.
- W62371999 creator A5009969778 @default.
- W62371999 creator A5017276343 @default.
- W62371999 creator A5021655049 @default.
- W62371999 creator A5057272279 @default.
- W62371999 creator A5065377148 @default.
- W62371999 creator A5083295372 @default.
- W62371999 date "2002-12-01" @default.
- W62371999 modified "2023-09-26" @default.
- W62371999 title "Acceleration of Mouse Mammary Tumor Virus-Induced Murine Mammary Tumorigenesis by a p53172H Transgene" @default.
- W62371999 cites W1514414732 @default.
- W62371999 cites W1530948141 @default.
- W62371999 cites W1545715882 @default.
- W62371999 cites W1567404006 @default.
- W62371999 cites W1580945237 @default.
- W62371999 cites W1598625800 @default.
- W62371999 cites W1735408039 @default.
- W62371999 cites W1751787271 @default.
- W62371999 cites W1757839603 @default.
- W62371999 cites W1837895691 @default.
- W62371999 cites W185148111 @default.
- W62371999 cites W1859087996 @default.
- W62371999 cites W189949720 @default.
- W62371999 cites W1909617247 @default.
- W62371999 cites W1964999053 @default.
- W62371999 cites W1982288359 @default.
- W62371999 cites W1988365075 @default.
- W62371999 cites W2005677707 @default.
- W62371999 cites W2006982410 @default.
- W62371999 cites W2008465346 @default.
- W62371999 cites W2014669590 @default.
- W62371999 cites W2014795526 @default.
- W62371999 cites W2023071161 @default.
- W62371999 cites W2023496422 @default.
- W62371999 cites W2027345413 @default.
- W62371999 cites W2028220014 @default.
- W62371999 cites W2040730301 @default.
- W62371999 cites W2063187123 @default.
- W62371999 cites W2066861312 @default.
- W62371999 cites W2074636517 @default.
- W62371999 cites W2082178034 @default.
- W62371999 cites W2098584421 @default.
- W62371999 cites W2119502087 @default.
- W62371999 cites W2121116477 @default.
- W62371999 cites W2124206672 @default.
- W62371999 cites W2127129747 @default.
- W62371999 cites W2129172191 @default.
- W62371999 cites W2129605816 @default.
- W62371999 cites W2142154935 @default.
- W62371999 cites W2143324424 @default.
- W62371999 cites W2144387226 @default.
- W62371999 cites W2147135997 @default.
- W62371999 cites W2151537482 @default.
- W62371999 cites W2158228414 @default.
- W62371999 cites W2185924837 @default.
- W62371999 cites W2288636961 @default.
- W62371999 cites W2326732193 @default.
- W62371999 cites W2341138542 @default.
- W62371999 cites W2404058635 @default.
- W62371999 cites W2576734941 @default.
- W62371999 cites W307508395 @default.
- W62371999 cites W4248142848 @default.
- W62371999 cites W4254731271 @default.
- W62371999 cites W83698905 @default.
- W62371999 doi "https://doi.org/10.1016/s0002-9440(10)64500-2" @default.
- W62371999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850916" @default.
- W62371999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466138" @default.
- W62371999 hasPublicationYear "2002" @default.
- W62371999 type Work @default.
- W62371999 sameAs 62371999 @default.
- W62371999 citedByCount "20" @default.
- W62371999 countsByYear W623719992012 @default.
- W62371999 countsByYear W623719992013 @default.
- W62371999 countsByYear W623719992020 @default.
- W62371999 countsByYear W623719992021 @default.
- W62371999 crossrefType "journal-article" @default.
- W62371999 hasAuthorship W62371999A5005326043 @default.
- W62371999 hasAuthorship W62371999A5009969778 @default.
- W62371999 hasAuthorship W62371999A5017276343 @default.
- W62371999 hasAuthorship W62371999A5021655049 @default.
- W62371999 hasAuthorship W62371999A5057272279 @default.
- W62371999 hasAuthorship W62371999A5065377148 @default.
- W62371999 hasAuthorship W62371999A5083295372 @default.
- W62371999 hasBestOaLocation W623719992 @default.
- W62371999 hasConcept C102230213 @default.
- W62371999 hasConcept C104317684 @default.
- W62371999 hasConcept C121608353 @default.
- W62371999 hasConcept C141035611 @default.
- W62371999 hasConcept C1491633281 @default.
- W62371999 hasConcept C153911025 @default.
- W62371999 hasConcept C2776187077 @default.
- W62371999 hasConcept C2779777497 @default.
- W62371999 hasConcept C2780932548 @default.
- W62371999 hasConcept C502942594 @default.
- W62371999 hasConcept C530470458 @default.
- W62371999 hasConcept C54355233 @default.