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- W62408197 abstract "The idea of fetal origins of adult degenerative diseases and early-life programming of late-life health and survival is being actively discussed in the scientific literature. This idea is also important for understanding the historical changes in human lifespan through the mechanism of technophysio evolution as suggested by Robert Fogel and Dora Costa. Can this new fascinating concept also be useful to understand (at least partially) the observed sex disparities in adult health and longevity? Are the long-lasting effects of early-life conditions identical for both sexes, or, on the contrary, are they sex-specific? These questions stimulated us to conduct the present pilot exploratory study on the sex specificity of late-life health outcomes for early-life effects. In this study we explored the effects of early-life conditions on adult lifespan of 13,000 persons using methodology of historical follow-up study of extinct birth cohorts (members of European aristocratic families born in 1800-1880). Using the method of multivariate regression with nominal predictor variables for individual lifespan as outcome variable, we found that sex differences in adult life span are indeed modulated by early-life events and conditions. Specifically, we found that such variables as (1) month of birth, (2) father's age at person's conception, (3) birth order (first-born status) have statistically significant effects on adult lifespan (life expectancy at age 30) in females, but not in males. Female lifespan has bimodal distribution according to the month of birth (M-shaped curve). Women born in May or December live longer lives compared to those born in February or August, while male lifespan is less affected by the season of birth in our historical dataset. Daughters born to younger fathers (below 30 years) or old fathers (above 45 years) live significantly shorter lives, while sons are less affected by paternal age at conception. First-born daughters live longer lives, while firstborn sons are not affected by their first-born status. The findings of this pilot exploratory study provide important scientific justification for a subsequent large-scale research project on related topic. Gavrilova, N.S. et al., Early-life predictors of human longevity”" @default.
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- W62408197 date "2001-01-01" @default.
- W62408197 modified "2023-09-24" @default.
- W62408197 title "Early-life Predictors of Human Longevity" @default.
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