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- W624583967 abstract "Hearing sensitivity in normal mammals is drastically improved by about 40 dB by a cochlear amplifier, which is involved with mechano-electrical transduction (MET) located within the stereocilia on the apex of the cells modulating receptor potentials in response to hair cell bundle deflection, and electromotility placed in the outer hair cell (OHC) lateral wall triggering changes in the OHC length in response to the receptor potentials. While MET has been observed in both inner and outer hair cells of non-mammals and mammals, electromotility has been only observed in OHC of mammals. Recently, it has reported that OHC electromotility requires a voltage-dependent membrane based motor protein, prestin which is a member of solute carrier (SLC) 26 anion transporter family. That is, the presence of prestin is essential for the OHC electromotility and for cochlear amplification. Therefore, this paper deals with the recent studies identifying the relationship between prestin and electromotility, the recent findings of the structure and function of prestin, and the recent prestin-related topics." @default.
- W624583967 created "2016-06-24" @default.
- W624583967 creator A5038154691 @default.
- W624583967 date "2011-12-01" @default.
- W624583967 modified "2023-09-24" @default.
- W624583967 title "Prestin and Motility of the Cochlear Outer Hair Cell" @default.
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