FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W624584784> ?p ?o ?g. }

• W624584784 endingPage "3150" @default.
• W624584784 startingPage "3147" @default.
• W624584784 abstract "Twenty-five novel imidazole N-H substituted Daclatasvir (BMS-790052, DCV) analogues (8a-8y) were designed and synthesized as potential prodrugs. Structure modifications were performed in order to improve potency and pharmacokinetic (PK) properties. All target compounds were evaluated in a hepatitis C virus (HCV) genotype 1b replicon, and the 2-oxoethyl acetate substituted compound 8t showed similar anti-HCV activity (EC50 = 0.08 nM) to that of the lead compound Daclatasvir. Moreover, the utility of prodrug 8t was demonstrated through similar exposure of the parent compound when the prodrugs were dosed in vivo. PK studies showed that prodrug 8t was an ideal candidate for a slower and sustained release form of Daclatasvir." @default.
• W624584784 created "2016-06-24" @default.
• W624584784 creator A5000432967 @default.
• W624584784 creator A5008762233 @default.
• W624584784 creator A5032868650 @default.
• W624584784 creator A5049078993 @default.
• W624584784 creator A5058352448 @default.
• W624584784 creator A5067483347 @default.
• W624584784 creator A5082400478 @default.
• W624584784 creator A5089412876 @default.
• W624584784 date "2015-08-01" @default.
• W624584784 modified "2023-10-16" @default.
• W624584784 title "Design and synthesis of imidazole N–H substituted amide prodrugs as inhibitors of hepatitis C virus replication" @default.
• W624584784 cites W1980095859 @default.
• W624584784 cites W2014285805 @default.
• W624584784 cites W2025564897 @default.
• W624584784 cites W2033058866 @default.
• W624584784 cites W2039422277 @default.
• W624584784 cites W2059183805 @default.
• W624584784 cites W2070587341 @default.
• W624584784 cites W2079295092 @default.
• W624584784 cites W2087709256 @default.
• W624584784 cites W2089962959 @default.
• W624584784 cites W2115610036 @default.
• W624584784 cites W2144742120 @default.
• W624584784 cites W2166962970 @default.
• W624584784 cites W2314619766 @default.
• W624584784 doi "https://doi.org/10.1016/j.bmcl.2015.06.006" @default.
• W624584784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26077493" @default.
• W624584784 hasPublicationYear "2015" @default.
• W624584784 type Work @default.
• W624584784 sameAs 624584784 @default.
• W624584784 citedByCount "11" @default.
• W624584784 countsByYear W6245847842018 @default.
• W624584784 countsByYear W6245847842019 @default.
• W624584784 countsByYear W6245847842020 @default.
• W624584784 countsByYear W6245847842022 @default.
• W624584784 countsByYear W6245847842023 @default.
• W624584784 crossrefType "journal-article" @default.
• W624584784 hasAuthorship W624584784A5000432967 @default.
• W624584784 hasAuthorship W624584784A5008762233 @default.
• W624584784 hasAuthorship W624584784A5032868650 @default.
• W624584784 hasAuthorship W624584784A5049078993 @default.
• W624584784 hasAuthorship W624584784A5058352448 @default.
• W624584784 hasAuthorship W624584784A5067483347 @default.
• W624584784 hasAuthorship W624584784A5082400478 @default.
• W624584784 hasAuthorship W624584784A5089412876 @default.
• W624584784 hasConcept C104317684 @default.
• W624584784 hasConcept C108215921 @default.
• W624584784 hasConcept C112705442 @default.
• W624584784 hasConcept C135763542 @default.
• W624584784 hasConcept C150903083 @default.
• W624584784 hasConcept C159047783 @default.
• W624584784 hasConcept C18103114 @default.
• W624584784 hasConcept C185592680 @default.
• W624584784 hasConcept C202751555 @default.
• W624584784 hasConcept C207001950 @default.
• W624584784 hasConcept C21951064 @default.
• W624584784 hasConcept C22744801 @default.
• W624584784 hasConcept C2522874641 @default.
• W624584784 hasConcept C2776408679 @default.
• W624584784 hasConcept C2776979040 @default.
• W624584784 hasConcept C2778327999 @default.
• W624584784 hasConcept C2778439535 @default.
• W624584784 hasConcept C2780040827 @default.
• W624584784 hasConcept C2780874372 @default.
• W624584784 hasConcept C2780880337 @default.
• W624584784 hasConcept C552990157 @default.
• W624584784 hasConcept C55493867 @default.
• W624584784 hasConcept C57992300 @default.
• W624584784 hasConcept C71240020 @default.
• W624584784 hasConcept C71924100 @default.
• W624584784 hasConcept C86803240 @default.
• W624584784 hasConcept C98274493 @default.
• W624584784 hasConceptScore W624584784C104317684 @default.
• W624584784 hasConceptScore W624584784C108215921 @default.
• W624584784 hasConceptScore W624584784C112705442 @default.
• W624584784 hasConceptScore W624584784C135763542 @default.
• W624584784 hasConceptScore W624584784C150903083 @default.
• W624584784 hasConceptScore W624584784C159047783 @default.
• W624584784 hasConceptScore W624584784C18103114 @default.
• W624584784 hasConceptScore W624584784C185592680 @default.
• W624584784 hasConceptScore W624584784C202751555 @default.
• W624584784 hasConceptScore W624584784C207001950 @default.
• W624584784 hasConceptScore W624584784C21951064 @default.
• W624584784 hasConceptScore W624584784C22744801 @default.
• W624584784 hasConceptScore W624584784C2522874641 @default.
• W624584784 hasConceptScore W624584784C2776408679 @default.
• W624584784 hasConceptScore W624584784C2776979040 @default.
• W624584784 hasConceptScore W624584784C2778327999 @default.
• W624584784 hasConceptScore W624584784C2778439535 @default.
• W624584784 hasConceptScore W624584784C2780040827 @default.
• W624584784 hasConceptScore W624584784C2780874372 @default.
• W624584784 hasConceptScore W624584784C2780880337 @default.
• W624584784 hasConceptScore W624584784C552990157 @default.
• W624584784 hasConceptScore W624584784C55493867 @default.
• W624584784 hasConceptScore W624584784C57992300 @default.
• W624584784 hasConceptScore W624584784C71240020 @default.

• next