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- W624972334 abstract "In the present study, the chemotherapeutic potential of zerumbone towards HeLa cellline and cervical cancer induced in female Balblc mice were investigated. Thechemotherapeutic potential of zerumbone was compared with cisplatin, a commercialdrug used to treat cervical cancer. The cytotoxicity of both zerumbone and cisplatintowards HeLa cell line were determined using MTT assay. The findings showed that theICso value (* S.E.M) of zerumbone towards HeLa cell line was 11.3 * 0.2 pM, whilstthe ICSO value of cisplatin was 7.5 * 0.3 pM. Both IC50 values for zerumbone andcisplatin fall within the very significant group based on the National Cancer InstituteStandard. All the values are significant (P < 0.01). The HeLa cells were treated withICso concentration of zerumbone and cisplatin respectively for morphological analysisusing inverted microscopy. The results showed significant growth retardation in HeLaiiicells exposed to zerumbone and cisplatin at 24,48 and 72 hours, whilst the control cellsare well spread and confluent. Pregnant female Balblc mice were exposed toDiethylstilbestrol (DES) at 13'~to 1 8 '~d ay of gestation. The progeny of the DESexposedmothers developed cervical intra-epithelial neoplasia. These progenies weredivided into 4 groups and were either given treatment with normal saline, 8 mglkgzerumbone, 16 mg/kg zerumbone and 10 mg/kg cisplatin. The mice were sacrificedfollowing the treatments and their cervical tissues subjected to histological examination,TUNEL Assay and immunohistochemistry. The histological examination revealed thatboth zerumbone and cisplatin treatments were able to inhibit the progression of cervicaldysplasia fiom becoming more severe dysplasia (CIN 3). In the mice treated withnormal saline, the dysplasia had progressed to CIN 3 (severe dysplasia). The TUNELassay micrographs showed that there was no apoptosis in the cervical tissue of thenormal saline treated mice compared to the cervical tissue of mice treated withzerumbone and cisplatin, where abundant apoptotic cells were noticed. The levels ofserum IL-6 were suppressed in mice treated with zerumbone and cisplatin. In contrast,mice treated with normal saline showed elevated level of serum IL-6.Immunohistochemistry study demonstrated that the production level of membranebound IL-6 receptor had been suppressed by the treatment of zerumbone and cisplatincompared to mice treated with normal saline which had a higher concentration ofmembrane bound IL-6 receptors. This showed that both zerumbone and cisplatin act ina similar manner in vivo and in vitro. In conclusion, it is suggested that zerumbone, aplant derived compound, could be explored as a new anti cancer agent for treatingcervical cancer in the future." @default.
- W624972334 created "2016-06-24" @default.
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- W624972334 date "2007-03-01" @default.
- W624972334 modified "2023-09-27" @default.
- W624972334 title "Effects Of Zerumbone From Zingiber Zerumbet On Cervicalcancer-Induced Female Balb/C Mice" @default.
- W624972334 hasPublicationYear "2007" @default.
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