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- W625415087 abstract "The effect of photodynamic therapy (PDT) using Mono-L-aspartyl chlorin e6 (ME2906) on vascular system was examined. Examination of blood flow condition was made by X-ray examination after circulation of barium sulfate on PDT-performed mice and microscopic observation of microvascular change on PDT-performing mice. The blood flow stasis and white thrombus formation were found in the vessels and vascular-shut-down was observed at the area performed PDT. According to electron microscopic observation, some organelle especially endoplasmic reticulum in tumor vascular endothelial cells after PDT were degenerated. On the other hand PDT did not accelerate on platelet aggregation or coagulation in vitro. These results suggest that vascular-shut-down effects are involved in the tumor therapeutic effects of PDT using ME2906. At that time PDT seems to form thrombus through the effects on the endothelial cells but not on the platelets or coagulation factors directly." @default.
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- W625415087 date "1995-01-01" @default.
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- W625415087 title "Effects of photodynamic therapy using Mono-L-aspartyl Chlorin e6 on vascular system." @default.
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- W625415087 doi "https://doi.org/10.2530/jslsm1980.16.supplement_169" @default.
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