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- W62571176 abstract "Publisher Summary This chapter describes the occurrence of cytopathic hypoxia in septic shock. The term “sepsis” refers to the systemic response of an organism to infection. Septic shock refers to overwhelming sepsis resulting in organ hypoperfusion and decreased blood pressure. The incidence of human sepsis is gradually rising as a result of an aging population and the increasing severity of acquired forms of immunodeficiency. The de-energization in sepsis may contribute directly or indirectly to dysfunction and to apoptosis and necrosis. Because most adenosine triphosphate (ATP) is synthesized aerobically, coupled to the reduction of cellular O 2 to H 2 O, the role of O 2 kinetics in sepsis is a major focus. Although evidence for diffuse tissue hypoxia in sepsis is lacking, regional hypoxia is hypothesized to play a substantial role in the cause of multiple organ dysfunction. Low cardiac output, anemia, and arterial hypoxia might occur singly or in combination in sepsis. Human sepsis is characterized by a hyperdynamic circulation with elevated mixed-venous oxygen content in the setting of regional or systemic metabolic acidosis and hyperlactatemia that are the markers of increased anaerobic respiration." @default.
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- W62571176 date "2000-01-01" @default.
- W62571176 modified "2023-10-16" @default.
- W62571176 title "Cytopathic hypoxia in septic shock" @default.
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- W62571176 doi "https://doi.org/10.1016/s1064-6000(00)80005-8" @default.
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