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- W62576319 abstract "The JAK family of nonreceptor PTKs were discovered by appli-cation of PCR, using degenerate oligonucleotide primers based on highly conserved elements located within the catalytic domain of all PTKs.165–167,170,171 At the time of discovery they were but two sequences from a multitude of previously unknown PTK-related sequences emerging from this PCR-based screen (earning the laboratory code-name of J ust A nother K inase; or JAK). Ultimately, the discovery that these proteins possess two kinase-related domains suggested a more learned justification of the acronym ‘JAK’, as the J A nus K inases, named after the Roman god Janus, who possessed two faces.172 The contemporaneous discovery of Tyk2,168,169 a third member of this class of PTKs, and the more recent discovery of JAK3,173–176 complete a cast of four JAK family members in the human (and mouse) genome. More recently, a Drosophila melanogaster family member (named, with typical fly community imagination, hopscotch) has been discovered,177 and a piscine homologue of JAK1, (known as F-JAK and only as an unpublished sequence from its accession number in the Genbank database), has been isolated from carp (Cyprius carpio). A further two piscine JAK family members have been isolated from the Zebrafish (Danio rerio), and appear to be JAK1 and JAK2 homologues (Oates, Irvine and Wilks, unpublished data)." @default.
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- W62576319 date "1996-01-01" @default.
- W62576319 modified "2023-09-25" @default.
- W62576319 title "The JAK Family of Protein Tyrosine Kinases" @default.
- W62576319 doi "https://doi.org/10.1007/978-3-662-22050-4_3" @default.
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