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• W627295035 endingPage "76" @default.
• W627295035 startingPage "43" @default.
• W627295035 abstract "Despite significant progress in the past two decades, the formation and homeostasis of multicellular structures in musculoskeletal tissues remains a major challenge to be solved. Although assembly approaches, such as bioprinting and directed assembly of tissue building blocks, are powerful tools for mimicking cellular organization of native tissues, one should bear in mind that cells are highly connected to their microenvironment and their fate changes with the spatiotemporal release of growth factors from their microenvironment. Improper signals can direct cells toward apoptosis or carcinogenic pathways with undesired and harmful side effects. The proper cellular commitment toward a selected number of lineages is critical to mimicking the functionality of the native tissue. Growth factors play a critical role as signaling molecules to regulate cell behavior during embryonic development and postnatal tissue regeneration. Leveraging growth factors for the full benefit of tissue engineering in the context of musculoskeletal tissues depends on our understanding of molecular regulatory mechanisms involved in natural development of different compartments of the musculoskeletal system. The first part of this chapter provides an overview of the molecular regulatory development for embryonic development of the musculoskeletal system. In brief, Wnt and Shh signaling are the main regulators of myogenic lineage differentiation, whereas combination of BMP4 and Notch signaling sustain a certain population of muscle progenitor cells in an undifferentiated state. Tendon development is regulated by the interplay between TGF-β, Wnt, and FGF signaling pathways. Formation of trunk and back muscles depends on the secretion of FGF-4 and FGF-8 from myotome, whereas formation of limb tendons is regulated by the inductive effect of Wnt 3, 6, and 7a excreted from ectoderm. In addition, excretion of TGF-β from differentiating muscle and cartilage tissues at the late stages of tissue development causes the recruitment of a second wave of tendon progenitor cells, which contribute to the formation of connections between the developing tendons, muscle, and skeletal tissues. Articular cartilage is a highly organized tissue composed of multiple distinct zones with defined cell phenotypes, ECM composition, and growth factors. Formation and homeostasis of the complex organization of articular cartilage is regulated by various interactions between IGF, TGF-β, and BMP signaling pathways. Embryonic and postnatal bone tissue formation is a highly dynamic process and involves the reciprocal interactions between different cell types including MSCs, osteoprogenitors, and endothelial cells. Cortical bone formation involves several cross talks among Wnt, TGF-β, Ihh/PTHrP, and Notch signaling pathways. Unlike current approaches to bone tissue engineering, which mostly leads to the formation of spongiform bone, mimicking mechanisms of native cortical bone tissue formation can be a promising approach for engineering of tissue constructs with biomechanical properties similar to the native tissue. Growth factor-based tissue engineering by recapitulating regulatory mechanisms behind normal tissue development and homeostasis can be applied as an efficient approach to restore function of damaged musculoskeletal tissues. To this end, novel methodologies and technologies are needed to mimic in engineered constructs the natural pattern and gradient of multiple growth factors that exist in musculoskeletal tissues. In the second part of the chapter, recent advances in spatiotemporal release of growth factors from tissue engineering scaffolds and their presentation to the seeded cells are discussed." @default.
• W627295035 created "2016-06-24" @default.
• W627295035 creator A5056427455 @default.
• W627295035 creator A5082803320 @default.
• W627295035 creator A5091157658 @default.
• W627295035 date "2015-01-01" @default.
• W627295035 modified "2023-10-16" @default.
• W627295035 title "Growth factors for musculoskeletal tissue engineering" @default.
• W627295035 cites W1197465675 @default.
• W627295035 cites W1521657513 @default.
• W627295035 cites W1581446444 @default.
• W627295035 cites W1592231070 @default.
• W627295035 cites W1608008717 @default.
• W627295035 cites W1877254581 @default.
• W627295035 cites W1887141904 @default.
• W627295035 cites W1898242701 @default.
• W627295035 cites W1909152361 @default.
• W627295035 cites W1937108761 @default.
• W627295035 cites W1966909881 @default.
• W627295035 cites W1967880811 @default.
• W627295035 cites W1968592374 @default.
• W627295035 cites W1970532151 @default.
• W627295035 cites W1971904355 @default.
• W627295035 cites W1972023230 @default.
• W627295035 cites W1972359049 @default.
• W627295035 cites W1972607682 @default.
• W627295035 cites W1974543599 @default.
• W627295035 cites W1974708858 @default.
• W627295035 cites W1975471671 @default.
• W627295035 cites W1981471190 @default.
• W627295035 cites W1981944012 @default.
• W627295035 cites W1982376169 @default.
• W627295035 cites W1983888310 @default.
• W627295035 cites W1983920704 @default.
• W627295035 cites W1984363536 @default.
• W627295035 cites W1985140092 @default.
• W627295035 cites W1985606434 @default.
• W627295035 cites W1987662957 @default.
• W627295035 cites W1987927770 @default.
• W627295035 cites W1989579884 @default.
• W627295035 cites W1989579925 @default.
• W627295035 cites W1991073285 @default.
• W627295035 cites W1991344600 @default.
• W627295035 cites W1991492417 @default.
• W627295035 cites W1993623493 @default.
• W627295035 cites W1994151976 @default.
• W627295035 cites W1995394709 @default.
• W627295035 cites W1997862931 @default.
• W627295035 cites W2000156083 @default.
• W627295035 cites W2001386866 @default.
• W627295035 cites W2004266019 @default.
• W627295035 cites W2004602258 @default.
• W627295035 cites W2006107446 @default.
• W627295035 cites W2007609898 @default.
• W627295035 cites W2008311131 @default.
• W627295035 cites W2009186219 @default.
• W627295035 cites W2010410579 @default.
• W627295035 cites W2010926909 @default.
• W627295035 cites W2015890999 @default.
• W627295035 cites W2016849887 @default.
• W627295035 cites W2018449597 @default.
• W627295035 cites W2020700245 @default.
• W627295035 cites W2021345837 @default.
• W627295035 cites W2022218736 @default.
• W627295035 cites W2024295986 @default.
• W627295035 cites W2024471725 @default.
• W627295035 cites W2024691319 @default.
• W627295035 cites W2024963992 @default.
• W627295035 cites W2025247123 @default.
• W627295035 cites W2025898370 @default.
• W627295035 cites W2026201824 @default.
• W627295035 cites W2027600661 @default.
• W627295035 cites W2031126348 @default.
• W627295035 cites W2031486950 @default.
• W627295035 cites W2032740384 @default.
• W627295035 cites W2032896724 @default.
• W627295035 cites W2033524865 @default.
• W627295035 cites W2034458870 @default.
• W627295035 cites W2034486165 @default.
• W627295035 cites W2035740045 @default.
• W627295035 cites W2036079309 @default.
• W627295035 cites W2036575527 @default.
• W627295035 cites W2038641983 @default.
• W627295035 cites W2040155058 @default.
• W627295035 cites W2040471298 @default.
• W627295035 cites W2041205435 @default.
• W627295035 cites W2041406939 @default.
• W627295035 cites W2041745288 @default.
• W627295035 cites W2042860502 @default.
• W627295035 cites W2042932723 @default.
• W627295035 cites W2045545457 @default.
• W627295035 cites W2047652196 @default.
• W627295035 cites W2049257933 @default.
• W627295035 cites W2053293963 @default.
• W627295035 cites W2053660605 @default.
• W627295035 cites W2055600411 @default.
• W627295035 cites W2056195172 @default.
• W627295035 cites W2056835799 @default.

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