FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W62803312> ?p ?o ?g. }

• W62803312 endingPage "5957" @default.
• W62803312 startingPage "5944" @default.
• W62803312 abstract "Research Article15 December 1994free access Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. M.E. Cardenas M.E. Cardenas Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author C. Hemenway C. Hemenway Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author R.S. Muir R.S. Muir Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author R. Ye R. Ye Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author D. Fiorentino D. Fiorentino Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author J. Heitman J. Heitman Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author M.E. Cardenas M.E. Cardenas Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author C. Hemenway C. Hemenway Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author R.S. Muir R.S. Muir Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author R. Ye R. Ye Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author D. Fiorentino D. Fiorentino Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author J. Heitman J. Heitman Department of Genetics, Duke University Medical Center, Durham, NC 27710. Search for more papers by this author Author Information M.E. Cardenas1, C. Hemenway1, R.S. Muir1, R. Ye1, D. Fiorentino1 and J. Heitman1 1Department of Genetics, Duke University Medical Center, Durham, NC 27710. The EMBO Journal (1994)13:5944-5957https://doi.org/10.1002/j.1460-2075.1994.tb06940.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The peptidyl-prolyl isomerases FKBP12 and cyclophilin A (immunophilins) form complexes with the immunosuppressants FK506 and cyclosporin A that inhibit the phosphatase calcineurin. With the yeast two hybrid system, we detect complexes between FKBP12 and the calcineurin A catalytic subunit in both the presence and absence of FK506. Mutations in FKBP12 surface residues or the absence of the calcineurin B regulatory subunit perturb the FK506-dependent, but not the ligand-independent, FKBP12-calcineurin complex. By affinity chromatography, both FKBP12 and cyclophilin A bind calcineurin A in the absence of ligand, and FK506 and cyclosporin A respectively potentiate these interactions. Both in vivo and in vitro, the peptidyl-prolyl isomerase active sites are dispensable for ligand-independent immunophilin-calcineurin complexes. Lastly, by genetic analyses we demonstrate that FKBP12 modulates calcineurin functions in vivo. These findings reveal that immunophilins interact with calcineurin in the absence of exogenous ligands and suggest that immunosuppressants may take advantage of the inherent ability of immunophilins to interact with calcineurin. Previous ArticleNext Article Volume 13Issue 241 December 1994In this issue RelatedDetailsLoading ..." @default.
• W62803312 created "2016-06-24" @default.
• W62803312 creator A5029992879 @default.
• W62803312 creator A5037932444 @default.
• W62803312 creator A5043366850 @default.
• W62803312 creator A5048784088 @default.
• W62803312 creator A5052159588 @default.
• W62803312 creator A5060123660 @default.
• W62803312 date "1994-12-01" @default.
• W62803312 modified "2023-10-10" @default.
• W62803312 title "Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands." @default.
• W62803312 cites W1483202000 @default.
• W62803312 cites W1488647821 @default.
• W62803312 cites W1497188274 @default.
• W62803312 cites W1497947649 @default.
• W62803312 cites W1499287202 @default.
• W62803312 cites W1508345799 @default.
• W62803312 cites W1514235376 @default.
• W62803312 cites W1520817266 @default.
• W62803312 cites W1532903931 @default.
• W62803312 cites W1533596330 @default.
• W62803312 cites W1538787080 @default.
• W62803312 cites W1554245708 @default.
• W62803312 cites W1557416929 @default.
• W62803312 cites W1590715819 @default.
• W62803312 cites W1601157315 @default.
• W62803312 cites W1842374849 @default.
• W62803312 cites W1863217888 @default.
• W62803312 cites W1888736125 @default.
• W62803312 cites W19446119 @default.
• W62803312 cites W1967407965 @default.
• W62803312 cites W1967603109 @default.
• W62803312 cites W1969971113 @default.
• W62803312 cites W1970842110 @default.
• W62803312 cites W1971177037 @default.
• W62803312 cites W1976129849 @default.
• W62803312 cites W1977186059 @default.
• W62803312 cites W1978879981 @default.
• W62803312 cites W1982869248 @default.
• W62803312 cites W1984754431 @default.
• W62803312 cites W1985339191 @default.
• W62803312 cites W1986094270 @default.
• W62803312 cites W1991693950 @default.
• W62803312 cites W1998393335 @default.
• W62803312 cites W2002733361 @default.
• W62803312 cites W2005873886 @default.
• W62803312 cites W2010240180 @default.
• W62803312 cites W2012124354 @default.
• W62803312 cites W2016323373 @default.
• W62803312 cites W2017352502 @default.
• W62803312 cites W2018365938 @default.
• W62803312 cites W2020735298 @default.
• W62803312 cites W2021820849 @default.
• W62803312 cites W2022876115 @default.
• W62803312 cites W2023842903 @default.
• W62803312 cites W2024431372 @default.
• W62803312 cites W2024695552 @default.
• W62803312 cites W2024842574 @default.
• W62803312 cites W2026181894 @default.
• W62803312 cites W2032778685 @default.
• W62803312 cites W2041512157 @default.
• W62803312 cites W2046276016 @default.
• W62803312 cites W2048399816 @default.
• W62803312 cites W2051793369 @default.
• W62803312 cites W2052741482 @default.
• W62803312 cites W2053132428 @default.
• W62803312 cites W2060913542 @default.
• W62803312 cites W2062120260 @default.
• W62803312 cites W2062639699 @default.
• W62803312 cites W2063013559 @default.
• W62803312 cites W2064768072 @default.
• W62803312 cites W2070102173 @default.
• W62803312 cites W2077546649 @default.
• W62803312 cites W2084977836 @default.
• W62803312 cites W2089218510 @default.
• W62803312 cites W2089850443 @default.
• W62803312 cites W2090230494 @default.
• W62803312 cites W2090308278 @default.
• W62803312 cites W2091538386 @default.
• W62803312 cites W2096503469 @default.
• W62803312 cites W2099896929 @default.
• W62803312 cites W2108794906 @default.
• W62803312 cites W2109188826 @default.
• W62803312 cites W2119892511 @default.
• W62803312 cites W2129173045 @default.
• W62803312 cites W2141385342 @default.
• W62803312 cites W2142946131 @default.
• W62803312 cites W2165562991 @default.
• W62803312 cites W4240065971 @default.
• W62803312 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06940.x" @default.
• W62803312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/395570" @default.
• W62803312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7529175" @default.
• W62803312 hasPublicationYear "1994" @default.
• W62803312 type Work @default.
• W62803312 sameAs 62803312 @default.
• W62803312 citedByCount "154" @default.
• W62803312 countsByYear W628033122012 @default.
• W62803312 countsByYear W628033122013 @default.

• next