Matches in SemOpenAlex for { <https://semopenalex.org/work/W62837367> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W62837367 abstract "From first international conference on stable isotopes in chemistry, biology, and medicine; Argonne, lllinois, USA (9 May 1973). In proceedings of the first international conference on stable isotopes in chemistry, biology, and medicine. The 3-hydroxylation of diazepam to yield 3-hydroxy-diazepam was investigated in an attempt to study the NADPH-dependent oxygenation of nitrogen containing compounds. The source of oxygen was identified by high and low resolution mass spectrometry as molecular oxygen using separate microsomal incubations with /sup 18/O enriched H/sub 2/O and O/sub 2/. The /sup 18/O enriched acetic an hydride induced rearrangement of acetoxydiazepam to diazepara N-4-oxide was studied as a chemical model for the possible role of the Noxide as enzymatic intermediate, which undergoes N to C oxygen migration. The retained N- oxide /sup 16/O could be located in acetoxydiazepam by analyzing the parent ion and kev fragments. In a separate study, human plasma and urine levels of diazoxide were measured in four patients by stable isotope dilution-GC-mass fragmentography. d3-Diazoxide served as internal standard. Conditions were developed to prevent the exchange of the label during derivatization for GC and on column. Sensitivity by repetitive scanning over the parent ions was 1 ng diazoxide/sample. (ERB)" @default.
- W62837367 created "2016-06-24" @default.
- W62837367 creator A5003417820 @default.
- W62837367 creator A5045316297 @default.
- W62837367 creator A5054287235 @default.
- W62837367 creator A5058910169 @default.
- W62837367 creator A5062174660 @default.
- W62837367 creator A5071503350 @default.
- W62837367 date "1973-01-01" @default.
- W62837367 modified "2023-09-27" @default.
- W62837367 title "Stable isotope-mass spectrometry in drug metabolism and pharmacokinetics" @default.
- W62837367 hasPublicationYear "1973" @default.
- W62837367 type Work @default.
- W62837367 sameAs 62837367 @default.
- W62837367 citedByCount "0" @default.
- W62837367 crossrefType "journal-article" @default.
- W62837367 hasAuthorship W62837367A5003417820 @default.
- W62837367 hasAuthorship W62837367A5045316297 @default.
- W62837367 hasAuthorship W62837367A5054287235 @default.
- W62837367 hasAuthorship W62837367A5058910169 @default.
- W62837367 hasAuthorship W62837367A5062174660 @default.
- W62837367 hasAuthorship W62837367A5071503350 @default.
- W62837367 hasConcept C121332964 @default.
- W62837367 hasConcept C162356407 @default.
- W62837367 hasConcept C171679685 @default.
- W62837367 hasConcept C177322064 @default.
- W62837367 hasConcept C185592680 @default.
- W62837367 hasConcept C22117777 @default.
- W62837367 hasConcept C2776923573 @default.
- W62837367 hasConcept C43617362 @default.
- W62837367 hasConcept C62520636 @default.
- W62837367 hasConceptScore W62837367C121332964 @default.
- W62837367 hasConceptScore W62837367C162356407 @default.
- W62837367 hasConceptScore W62837367C171679685 @default.
- W62837367 hasConceptScore W62837367C177322064 @default.
- W62837367 hasConceptScore W62837367C185592680 @default.
- W62837367 hasConceptScore W62837367C22117777 @default.
- W62837367 hasConceptScore W62837367C2776923573 @default.
- W62837367 hasConceptScore W62837367C43617362 @default.
- W62837367 hasConceptScore W62837367C62520636 @default.
- W62837367 hasLocation W628373671 @default.
- W62837367 hasOpenAccess W62837367 @default.
- W62837367 hasPrimaryLocation W628373671 @default.
- W62837367 hasRelatedWork W1972927753 @default.
- W62837367 hasRelatedWork W1980942888 @default.
- W62837367 hasRelatedWork W1997948779 @default.
- W62837367 hasRelatedWork W2007480418 @default.
- W62837367 hasRelatedWork W2007644159 @default.
- W62837367 hasRelatedWork W2023464611 @default.
- W62837367 hasRelatedWork W2025736749 @default.
- W62837367 hasRelatedWork W2049599518 @default.
- W62837367 hasRelatedWork W2051387851 @default.
- W62837367 hasRelatedWork W2052269082 @default.
- W62837367 hasRelatedWork W2054831651 @default.
- W62837367 hasRelatedWork W2058526216 @default.
- W62837367 hasRelatedWork W2069657647 @default.
- W62837367 hasRelatedWork W2073570901 @default.
- W62837367 hasRelatedWork W2165629604 @default.
- W62837367 hasRelatedWork W2313745147 @default.
- W62837367 hasRelatedWork W2410593950 @default.
- W62837367 hasRelatedWork W2598911291 @default.
- W62837367 hasRelatedWork W3010569602 @default.
- W62837367 hasRelatedWork W3176578942 @default.
- W62837367 isParatext "false" @default.
- W62837367 isRetracted "false" @default.
- W62837367 magId "62837367" @default.
- W62837367 workType "article" @default.