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- W6285107 abstract "This chapter discusses the applications of aminoglycosides in the field of medicine. The origin of aminoglycoside antibiotics began with streptomycin 60 years ago. Isolated from Actinomyces griseus, streptomycin immediately found applications for the treatment against the tuberculosis-causing microorganism—Mycobacterium tuberculosis. This was the second antibiotic after penicillin to be used clinically. Throughout the coming years, a number of aminoglycosides were discovered with varying potencies for treating infections. However, therapeutic applications were diminished by the emergence of resistance to aminoglycosides by bacteria. Though widely known for binding to prokaryotic ribosomal RNA, aminoglycosides have more recently shown affinity for other nucleic acid targets. This opens door to a new area of therapeutic applications. This chapter outlines the history of aminoglycosides, from their discovery, structural elucidation, and mechanism of action to the current knowledge of mechanisms of action and resistance, toxicity, and novel nucleic acid targets. Owing to a number of recent reviews pertaining to some of these areas, particular emphasis is placed on the recently discovered aminoglycoside targets and their potential therapeutic applications." @default.
- W6285107 created "2016-06-24" @default.
- W6285107 creator A5002532676 @default.
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- W6285107 date "2006-01-01" @default.
- W6285107 modified "2023-10-01" @default.
- W6285107 title "An Expanding View of Aminoglycoside–Nucleic Acid Recognition" @default.
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