Matches in SemOpenAlex for { <https://semopenalex.org/work/W628727562> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W628727562 abstract "In this thesis, the detection of global proteomics alteration and changes in neuropeptide distribution caused by neuropathic pain in rat spinal cord tissue was the main focus. Neuropathic pain (NP) is a major clinical syndrome caused by disease or dysfunction of the nervous system and often mediated by neuronal networks in the spinal cord. The estimated prevalence of NP is 6-8% in general population. Only in the United States, the indirect cost associated with chronic pain has been estimated to 100 billion dollars each year and NP substantially contributes to this cost. So far, the underlying mechanisms of NP are not well understood. Proteomics techniques are commonly used in biology system studies, due to its high throughput, capability of unbiased analysis and sensitivity. It builds up a bridge to link genes, peptides, proteins, and the disease. Two proteomic/peptidomic approaches were developed, evaluated and discussed in this thesis. Both of them were further applied in the studies of neuropathic pain. First approach is a quantitative proteomic approach using liquid chromatography combined with Fourier transform mass spectrometry (LC-FTMS), which is developed for quantitative analysis of proteins originated from small central nervous system (CNS) samples. This approach was successfully applied in the study of the rat spinal cord tissue proteome in a neuropathic pain model. Another approach is using matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the visualization of the distribution of neuropeptides in rat spinal cord, which in the future will be applied in investigating the ongoing signal transmission under neuropathic pain conditions. Results provided by these two methods are of high importance for the general understanding of the underlying pathophysiological mechanisms and potential identification of new targets for novel treatment of neuropathic pain." @default.
- W628727562 created "2016-06-24" @default.
- W628727562 creator A5002270607 @default.
- W628727562 creator A5049037127 @default.
- W628727562 creator A5058097471 @default.
- W628727562 creator A5058999301 @default.
- W628727562 creator A5089780292 @default.
- W628727562 date "2015-01-01" @default.
- W628727562 modified "2023-09-23" @default.
- W628727562 title "Lateralized proteome response to the left and right side neuropathic pain in a rat model" @default.
- W628727562 hasPublicationYear "2015" @default.
- W628727562 type Work @default.
- W628727562 sameAs 628727562 @default.
- W628727562 citedByCount "0" @default.
- W628727562 crossrefType "journal-article" @default.
- W628727562 hasAuthorship W628727562A5002270607 @default.
- W628727562 hasAuthorship W628727562A5049037127 @default.
- W628727562 hasAuthorship W628727562A5058097471 @default.
- W628727562 hasAuthorship W628727562A5058999301 @default.
- W628727562 hasAuthorship W628727562A5089780292 @default.
- W628727562 hasConcept C104317684 @default.
- W628727562 hasConcept C104397665 @default.
- W628727562 hasConcept C126322002 @default.
- W628727562 hasConcept C169760540 @default.
- W628727562 hasConcept C185592680 @default.
- W628727562 hasConcept C2777107010 @default.
- W628727562 hasConcept C2780775167 @default.
- W628727562 hasConcept C2908647359 @default.
- W628727562 hasConcept C46111723 @default.
- W628727562 hasConcept C545706735 @default.
- W628727562 hasConcept C55493867 @default.
- W628727562 hasConcept C60644358 @default.
- W628727562 hasConcept C71924100 @default.
- W628727562 hasConcept C86803240 @default.
- W628727562 hasConcept C99454951 @default.
- W628727562 hasConceptScore W628727562C104317684 @default.
- W628727562 hasConceptScore W628727562C104397665 @default.
- W628727562 hasConceptScore W628727562C126322002 @default.
- W628727562 hasConceptScore W628727562C169760540 @default.
- W628727562 hasConceptScore W628727562C185592680 @default.
- W628727562 hasConceptScore W628727562C2777107010 @default.
- W628727562 hasConceptScore W628727562C2780775167 @default.
- W628727562 hasConceptScore W628727562C2908647359 @default.
- W628727562 hasConceptScore W628727562C46111723 @default.
- W628727562 hasConceptScore W628727562C545706735 @default.
- W628727562 hasConceptScore W628727562C55493867 @default.
- W628727562 hasConceptScore W628727562C60644358 @default.
- W628727562 hasConceptScore W628727562C71924100 @default.
- W628727562 hasConceptScore W628727562C86803240 @default.
- W628727562 hasConceptScore W628727562C99454951 @default.
- W628727562 hasLocation W6287275621 @default.
- W628727562 hasOpenAccess W628727562 @default.
- W628727562 hasPrimaryLocation W6287275621 @default.
- W628727562 hasRelatedWork W1964226949 @default.
- W628727562 hasRelatedWork W2029025847 @default.
- W628727562 hasRelatedWork W2031034158 @default.
- W628727562 hasRelatedWork W2090607827 @default.
- W628727562 hasRelatedWork W2107684736 @default.
- W628727562 hasRelatedWork W2108661799 @default.
- W628727562 hasRelatedWork W2114423804 @default.
- W628727562 hasRelatedWork W2122479814 @default.
- W628727562 hasRelatedWork W2163413806 @default.
- W628727562 hasRelatedWork W2209348267 @default.
- W628727562 hasRelatedWork W2350482211 @default.
- W628727562 hasRelatedWork W2375518393 @default.
- W628727562 hasRelatedWork W2655756947 @default.
- W628727562 hasRelatedWork W2794095032 @default.
- W628727562 hasRelatedWork W2886625454 @default.
- W628727562 hasRelatedWork W2923498555 @default.
- W628727562 hasRelatedWork W3011542839 @default.
- W628727562 hasRelatedWork W3117556981 @default.
- W628727562 hasRelatedWork W3135394774 @default.
- W628727562 hasRelatedWork W3159655960 @default.
- W628727562 isParatext "false" @default.
- W628727562 isRetracted "false" @default.
- W628727562 magId "628727562" @default.
- W628727562 workType "article" @default.