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- W628758800 abstract "The expression of protein-encoding genes in eukaryotes is regulated at multiple levels, including the initial synthesis of pre-mRNA in the nucleus, the various nuclear processing events that convert pre-mRNA to mRNA, mRNA transport to the cytoplasm, and mRNA translation and, ultimately, degradation in the cytoplasm. All steps are exquisitely controlled to orchestrate the production of protein at the appropriate time and at a suitable level. It follows that a critical step in this orchestration is the proper maintenance of mRNA stability, which is often regulated to influence the amount of encoded protein. Thus, determinants of the rate at which an mRNA is degraded are important regulators of gene expression. As a consequence, the availability of methods and tools to analyze how and when individual mRNAs are either stabilized or turned over is essential to understand this exciting area of biology. This chapter focuses on six broad areas of mRNA turnover. The methods to study mRNA decapping and the analysis of decapping activity and the kinetics of decapping to the reconstitution of complexes that promote decapping are described. The in vitro methods to analyze deadenylation are also discussed in the chapter. Methods to reconstitute and test the activities of nucleases that function in mRNA decay are presented, which addresses how to characterize and detect exoribonucleases and endoribonucleases." @default.
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- W628758800 date "2008-01-01" @default.
- W628758800 modified "2023-09-24" @default.
- W628758800 title "Preface" @default.
- W628758800 doi "https://doi.org/10.1016/s0076-6879(08)02631-1" @default.
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