FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W62877049> ?p ?o ?g. }

• W62877049 endingPage "39" @default.
• W62877049 startingPage "39" @default.
• W62877049 abstract "Development of immune responses to donor mismatched HLA (DSA) has been a major risk factor for Transplant Glomerulopathy (TG) leading to chronic rejection following kidney transplantation (KTx). The goal of this study is to determine the impact of development of de novo antibodies (Abs) to DSA in the development of immune responses to kidney associated self-antigens, collagen-IV (Col-IV) and fibronectin (FN) in the immunopathogenesis of TG. Pre- and post-Tx sera from biopsies proven TG (n = 26) and stable (n=10) recipients were analyzed for DSA and cytokines by Luminex. Development of Abs to Col-IV and FN were determined by ELISA. Fourty six and 15% of TG patients developed DSA and non-DSA HLA Abs respectively. More significantly, 76% (p < 0.001) of TG patients developed Abs to Col-IV FN. In contrast, only 20% of stable patients developed abs to these antigens. Further, kinetic analysis as well as quantification of Abs to Col-IV (282 ± 41 vs. 139 ± 32ng/ml, p < 0.001) and FN (241 ± 54 vs. 145 ± 36ng/ml, p < 0.001) in patients with DSA demonstrating 1.7 to 2 fold higher levels in comparison to the non-DSA group suggest that specific alloimmune responses may predispose for the induction of autoimmune responses. The serum cytokines analysis demonstrated increased levels of IFN-γ, IL-1β, IL-6, IL-17, TNF-α, GM-CSF, VEGF, TGF-β (p < 0.01) in TG compared to stable and pre-tx sera indicating ongoing inflammation induced by ligation of specific membrane antigens by the de novo developed Abs in TG patients. Our results demonstrate that KTx recipients with TG develop Abs to DSA and/or HLA de novo which strongly correlate with induction of immune responses to kidney associated self-antigens col-IV and FN. Further, sera from TG patients also demonstrated increased levels of proinflammatory and profibrotic cytokines (IFN-γ, IL-1β, IL-6, IL-17, TNF-α, GM-CSF, VEGF, TGF-β) suggesting that the specific binding of antigens by de novo developed Abs may contribute to the immunopathogenesis of TG following human KTx." @default.
• W62877049 created "2016-06-24" @default.
• W62877049 creator A5012937467 @default.
• W62877049 creator A5028436053 @default.
• W62877049 creator A5062032591 @default.
• W62877049 creator A5067760858 @default.
• W62877049 creator A5079368182 @default.
• W62877049 creator A5082082558 @default.
• W62877049 creator A5085996715 @default.
• W62877049 date "2012-10-01" @default.
• W62877049 modified "2023-10-14" @default.
• W62877049 title "48-OR" @default.
• W62877049 doi "https://doi.org/10.1016/j.humimm.2012.07.080" @default.
• W62877049 hasPublicationYear "2012" @default.
• W62877049 type Work @default.
• W62877049 sameAs 62877049 @default.
• W62877049 citedByCount "0" @default.
• W62877049 crossrefType "journal-article" @default.
• W62877049 hasAuthorship W62877049A5012937467 @default.
• W62877049 hasAuthorship W62877049A5028436053 @default.
• W62877049 hasAuthorship W62877049A5062032591 @default.
• W62877049 hasAuthorship W62877049A5067760858 @default.
• W62877049 hasAuthorship W62877049A5079368182 @default.
• W62877049 hasAuthorship W62877049A5082082558 @default.
• W62877049 hasAuthorship W62877049A5085996715 @default.
• W62877049 hasConcept C126322002 @default.
• W62877049 hasConcept C147483822 @default.
• W62877049 hasConcept C159654299 @default.
• W62877049 hasConcept C188280979 @default.
• W62877049 hasConcept C203014093 @default.
• W62877049 hasConcept C2776914184 @default.
• W62877049 hasConcept C2780091579 @default.
• W62877049 hasConcept C2780303639 @default.
• W62877049 hasConcept C3019514911 @default.
• W62877049 hasConcept C71924100 @default.
• W62877049 hasConcept C8891405 @default.
• W62877049 hasConceptScore W62877049C126322002 @default.
• W62877049 hasConceptScore W62877049C147483822 @default.
• W62877049 hasConceptScore W62877049C159654299 @default.
• W62877049 hasConceptScore W62877049C188280979 @default.
• W62877049 hasConceptScore W62877049C203014093 @default.
• W62877049 hasConceptScore W62877049C2776914184 @default.
• W62877049 hasConceptScore W62877049C2780091579 @default.
• W62877049 hasConceptScore W62877049C2780303639 @default.
• W62877049 hasConceptScore W62877049C3019514911 @default.
• W62877049 hasConceptScore W62877049C71924100 @default.
• W62877049 hasConceptScore W62877049C8891405 @default.
• W62877049 hasLocation W628770491 @default.
• W62877049 hasOpenAccess W62877049 @default.
• W62877049 hasPrimaryLocation W628770491 @default.
• W62877049 hasRelatedWork W1531388598 @default.
• W62877049 hasRelatedWork W1980588456 @default.
• W62877049 hasRelatedWork W2060320114 @default.
• W62877049 hasRelatedWork W2062929029 @default.
• W62877049 hasRelatedWork W2079077757 @default.
• W62877049 hasRelatedWork W2602026891 @default.
• W62877049 hasRelatedWork W2753009215 @default.
• W62877049 hasRelatedWork W2975193761 @default.
• W62877049 hasRelatedWork W3032431257 @default.
• W62877049 hasRelatedWork W4252947416 @default.
• W62877049 hasVolume "73" @default.
• W62877049 isParatext "false" @default.
• W62877049 isRetracted "false" @default.
• W62877049 magId "62877049" @default.
• W62877049 workType "article" @default.