FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W6288358> ?p ?o ?g. }

• W6288358 endingPage "1754" @default.
• W6288358 startingPage "1741" @default.
• W6288358 abstract "The management of cancer in the older aged person represents one of the major immediate challenges of medicine. The response to this challenge involves answers to the following questions: I. Who is old? Currently. 70 years of age may he considered the lower limit of senescence because the majority of age-related changes occur after this age. Individual estimates of life expectancy and functional reserve may be obtained by a comprehensive and time-consuming multidimensional geriatric assessment. The current instrument may be fine-tuned and new instruments, including laboratory tests of ageing. may be developed. 2. Why do older persons develop more cancer? It is clear that ageing tissues are more susceptible to late-stage carcinogen. Older persons may represent a natural monitor system for new environmental carcinogens, and may also represent a fruitful ground to study the late stages of carcinogenesis. 3. Is cancer different in younger and older persons? Clearly. the behaviour of some tumors. including acute myeloid leukaemia, non-Hodgkin's lymphoma and breast cancer change with the age of the patient. The mechanisms of these changes that may involve both the tumour cell and the tumour host are poorly understood. 4. Can cancer he prevented in older individuals? Chemoprevention offers a new horizon of possibilities for cancer prevention: older persons may benefit most from chemoprevention due to increased susceptibility to environmental carcinogens. Screening tests may become more accurate in older individuals due to increased prevalence of cancer. hut may he less beneficial due to more limited patient life expectancy. 5. Do older persons benefit from cytotoxic treatment? The answer to this question partly stands on proper patient selection. partly on the development of safer forms of cancer treatment and prudent use of antidotes to chemotherapy toxicity. 6. What is the cost of treating older cancer patients? The treatment of older patients is generally more costly. This cost should be assessed against the cost of not treating cancer and promoting functional dependence. which by itself is extremely costly. 7. What are the endpoints of clinical trials in older cancer patients? With more limited life expectancy. the effect of treatment on quality of life is paramount. Reliable assessment of quality of life is essential for interpreting clinical trials in older individuals. 2000 Elsevier Science Ltd. All rights reserved." @default.
• W6288358 created "2016-06-24" @default.
• W6288358 creator A5072289832 @default.
• W6288358 date "2000-09-01" @default.
• W6288358 modified "2023-10-10" @default.
• W6288358 title "Geriatric oncology" @default.
• W6288358 cites W111108193 @default.
• W6288358 cites W141365462 @default.
• W6288358 cites W15220330 @default.
• W6288358 cites W1574826837 @default.
• W6288358 cites W1811037815 @default.
• W6288358 cites W1840259197 @default.
• W6288358 cites W1868843221 @default.
• W6288358 cites W1880028535 @default.
• W6288358 cites W1913553855 @default.
• W6288358 cites W1913623456 @default.
• W6288358 cites W1924320258 @default.
• W6288358 cites W1964237354 @default.
• W6288358 cites W1967077867 @default.
• W6288358 cites W1970938866 @default.
• W6288358 cites W1973389038 @default.
• W6288358 cites W1973940674 @default.
• W6288358 cites W1975407158 @default.
• W6288358 cites W1975844390 @default.
• W6288358 cites W1978438328 @default.
• W6288358 cites W1989789036 @default.
• W6288358 cites W1991306483 @default.
• W6288358 cites W1993166557 @default.
• W6288358 cites W1994775423 @default.
• W6288358 cites W1999094883 @default.
• W6288358 cites W2004408473 @default.
• W6288358 cites W2005967824 @default.
• W6288358 cites W2013257287 @default.
• W6288358 cites W2018953408 @default.
• W6288358 cites W2022864747 @default.
• W6288358 cites W2029932732 @default.
• W6288358 cites W2030493046 @default.
• W6288358 cites W2033067173 @default.
• W6288358 cites W2033517697 @default.
• W6288358 cites W2037121645 @default.
• W6288358 cites W2038793941 @default.
• W6288358 cites W2040264941 @default.
• W6288358 cites W2040630358 @default.
• W6288358 cites W2054153424 @default.
• W6288358 cites W2058370318 @default.
• W6288358 cites W2064604640 @default.
• W6288358 cites W2064949019 @default.
• W6288358 cites W2067098675 @default.
• W6288358 cites W2067382939 @default.
• W6288358 cites W2068714195 @default.
• W6288358 cites W2069277451 @default.
• W6288358 cites W2072031685 @default.
• W6288358 cites W2075776119 @default.
• W6288358 cites W2082118943 @default.
• W6288358 cites W2083113766 @default.
• W6288358 cites W2092849089 @default.
• W6288358 cites W2094127871 @default.
• W6288358 cites W2096657471 @default.
• W6288358 cites W2098378046 @default.
• W6288358 cites W2098856785 @default.
• W6288358 cites W2100630086 @default.
• W6288358 cites W2102235447 @default.
• W6288358 cites W2104755629 @default.
• W6288358 cites W2107576812 @default.
• W6288358 cites W2108262041 @default.
• W6288358 cites W2109802639 @default.
• W6288358 cites W2112013259 @default.
• W6288358 cites W2133244075 @default.
• W6288358 cites W2145188374 @default.
• W6288358 cites W2147436907 @default.
• W6288358 cites W2149938672 @default.
• W6288358 cites W2154433065 @default.
• W6288358 cites W2154692607 @default.
• W6288358 cites W2157796596 @default.
• W6288358 cites W2161633429 @default.
• W6288358 cites W2172174356 @default.
• W6288358 cites W2178809990 @default.
• W6288358 cites W2187673583 @default.
• W6288358 cites W2248522132 @default.
• W6288358 cites W2257461724 @default.
• W6288358 cites W2322424896 @default.
• W6288358 cites W2409870340 @default.
• W6288358 cites W2410065909 @default.
• W6288358 cites W2412541837 @default.
• W6288358 cites W2417787916 @default.
• W6288358 cites W2474317338 @default.
• W6288358 cites W24920798 @default.
• W6288358 cites W2668112190 @default.
• W6288358 cites W4297853659 @default.
• W6288358 doi "https://doi.org/10.1016/s0959-8049(00)00169-6" @default.
• W6288358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10974621" @default.
• W6288358 hasPublicationYear "2000" @default.
• W6288358 type Work @default.
• W6288358 sameAs 6288358 @default.
• W6288358 citedByCount "219" @default.
• W6288358 countsByYear W62883582012 @default.
• W6288358 countsByYear W62883582013 @default.
• W6288358 countsByYear W62883582014 @default.

• next