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- W62939578 abstract "X-ray crystallography is one of the most important methods in structural biology. The availability of heavy atom derivatives of proteins facilitates the application of the crystallographic MAD structure solution technique. Structural data of atomic resolution allow detailed statements about reaction mechanisms of enzymes. Aldose reductase belongs to a class of enzymes reducing Glucose to Sorbitol. The inhibition of this enzyme is relevant for the treatment of symptoms resulting from diabetes mellitus.In the present thesis, the structure of Aldose Reductase was determined by means of the MAD method. A structure refinement result at 0.9 Angstrom was confirmed with the experimental (MAD) electron density map. Thereby, multiple amino acid conformations and water networks were analyzed in detail.Furthermore, the thesis is concerned with the development and application of the software SitCom, which compares different heavy atom substructures of proteins systematically. The substructures are very important intermediate results of the MAD (and other) methods. Thus, SitCom contributes to the improvement of macromolecular structure solution. The application of the program yielded useful statements about recommended strategies when using the MAD technique." @default.
- W62939578 created "2016-06-24" @default.
- W62939578 creator A5010350313 @default.
- W62939578 date "2022-02-20" @default.
- W62939578 modified "2023-10-01" @default.
- W62939578 title "Studies on the Crystallographic Phasing of Proteins: Substructure Validation and MAD-phased Electron Density Maps at Atomic Resolution" @default.
- W62939578 doi "https://doi.org/10.53846/goediss-1987" @default.
- W62939578 hasPublicationYear "2022" @default.
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