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- W62993428 abstract "We verified the effects of sleep deprivation on blood and liver oxidative status of rats. Thirty male rats, living under controlled conditions with chow pellets and water ad libitum, were housed individually and signed as control (CTR), sleep deprived for 96h by the platform technique (SD-96h) and SD-96h recovered for 24h (REB) groups. Immediately after sleep deprivation blood and liver samples were collected to measure the levels of: Cu/Zn superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total glutathione (tGSH) and lipid peroxidation potential accessed as thiobarbituric acid reactive substances (TBARS). Body weight (BW) was strictly reduced in SD-96h (−6.23±2.58%) and REB (−7.10±2.31%) groups compared to CTR (+1.08±1.54%). Blood parameters showed reduced erythrocyte tGSH in SD-96h and REB groups compared to CTR. Meanwhile, liver oxidative stress markers showed reductions in SD-96h and REB groups on tGSH, CAT and TBARS levels. Correlation analysis showed a relationship between BW changes and erythrocyte tGSH (r=0.65), liver tGSH (r=54), liver CAT (r=0.73) and liver TBARS (r=0.49). Although reductions in erythrocyte and liver tGSH and liver CAT could suggest that sleep deprivation produces oxidative stress, it was not reinforced by blood and liver TBARS. Further, the correlation between all oxidative stress parameters modified by sleep deprivation and BW changes are in line to the proposal that metabolic status modifies free radical-scavenging system, and therefore it is important to differentiate the effects of BW reduction and sleep disturbance itself." @default.
- W62993428 created "2016-06-24" @default.
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- W62993428 date "2006-03-01" @default.
- W62993428 modified "2023-09-26" @default.
- W62993428 title "METABOLIC STATUS DETERMINES CHANGES IN THE ANTIOXIDANT SYSTEM AND LIPOPEROXIDATION IN SLEEP DEPRIVED RATS" @default.
- W62993428 doi "https://doi.org/10.1096/fasebj.20.5.lb26-b" @default.
- W62993428 hasPublicationYear "2006" @default.
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