Matches in SemOpenAlex for { <https://semopenalex.org/work/W630074089> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W630074089 abstract "Animal models that mimic human cardiac disorders have been created to test potential therapeutic strategies. A key component to evaluating these strategies is to examine their effects on heart function. There are several techniques to measure in vivo cardiac mechanics (e.g., echocardiography, pressure/volume relations, etc.). Compared to echocardiography, real-time left ventricular (LV) pressure/volume analysis via catheterization is more precise and insightful in assessing LV function. Additionally, LV pressure/volume analysis provides the ability to instantaneously record changes during manipulations of contractility (e.g., β-adrenergic stimulation) and pathological insults (e.g., ischemia/reperfusion injury). In addition to the maximum (+dP/dt) and minimum (-dP/dt) rate of pressure change in the LV, an accurate assessment of LV function via several load-independent indexes (e.g., end systolic pressure volume relationship and preload recruitable stroke work) can be attained. Heart rate has a significant effect on LV contractility such that an increase in the heart rate is the primary mechanism to increase cardiac output (i.e., Bowditch effect). Thus, when comparing hemodynamics between experimental groups, it is necessary to have similar heart rates. Furthermore, a hallmark of many cardiomyopathy models is a decrease in contractile reserve (i.e., decreased Bowditch effect). Consequently, vital information can be obtained by determining the effects of increasing heart rate on contractility. Our and others data has demonstrated that the neuronal nitric oxide synthase (NOS1) knockout mouse has decreased contractility. Here we describe the procedure of measuring LV pressure/volume with increasing heart rates using the NOS1 knockout mouse model." @default.
- W630074089 created "2016-06-24" @default.
- W630074089 creator A5004118575 @default.
- W630074089 creator A5040074839 @default.
- W630074089 creator A5070905119 @default.
- W630074089 date "2015-06-14" @default.
- W630074089 modified "2023-10-18" @default.
- W630074089 title "Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect" @default.
- W630074089 cites W1562799989 @default.
- W630074089 cites W2025877507 @default.
- W630074089 cites W2040603631 @default.
- W630074089 cites W2043294986 @default.
- W630074089 cites W2081706813 @default.
- W630074089 cites W2113365234 @default.
- W630074089 cites W2145570802 @default.
- W630074089 cites W2150757211 @default.
- W630074089 cites W2163879269 @default.
- W630074089 cites W2166059511 @default.
- W630074089 doi "https://doi.org/10.3791/52618" @default.
- W630074089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4545210" @default.
- W630074089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26131569" @default.
- W630074089 hasPublicationYear "2015" @default.
- W630074089 type Work @default.
- W630074089 sameAs 630074089 @default.
- W630074089 citedByCount "7" @default.
- W630074089 countsByYear W6300740892016 @default.
- W630074089 countsByYear W6300740892017 @default.
- W630074089 countsByYear W6300740892018 @default.
- W630074089 crossrefType "journal-article" @default.
- W630074089 hasAuthorship W630074089A5004118575 @default.
- W630074089 hasAuthorship W630074089A5040074839 @default.
- W630074089 hasAuthorship W630074089A5070905119 @default.
- W630074089 hasBestOaLocation W6300740892 @default.
- W630074089 hasConcept C111566952 @default.
- W630074089 hasConcept C126322002 @default.
- W630074089 hasConcept C164705383 @default.
- W630074089 hasConcept C178853913 @default.
- W630074089 hasConcept C26635844 @default.
- W630074089 hasConcept C2777385415 @default.
- W630074089 hasConcept C2777953023 @default.
- W630074089 hasConcept C2778198053 @default.
- W630074089 hasConcept C2778271984 @default.
- W630074089 hasConcept C3018791406 @default.
- W630074089 hasConcept C39133596 @default.
- W630074089 hasConcept C48277249 @default.
- W630074089 hasConcept C519581460 @default.
- W630074089 hasConcept C71924100 @default.
- W630074089 hasConcept C80461066 @default.
- W630074089 hasConcept C84393581 @default.
- W630074089 hasConceptScore W630074089C111566952 @default.
- W630074089 hasConceptScore W630074089C126322002 @default.
- W630074089 hasConceptScore W630074089C164705383 @default.
- W630074089 hasConceptScore W630074089C178853913 @default.
- W630074089 hasConceptScore W630074089C26635844 @default.
- W630074089 hasConceptScore W630074089C2777385415 @default.
- W630074089 hasConceptScore W630074089C2777953023 @default.
- W630074089 hasConceptScore W630074089C2778198053 @default.
- W630074089 hasConceptScore W630074089C2778271984 @default.
- W630074089 hasConceptScore W630074089C3018791406 @default.
- W630074089 hasConceptScore W630074089C39133596 @default.
- W630074089 hasConceptScore W630074089C48277249 @default.
- W630074089 hasConceptScore W630074089C519581460 @default.
- W630074089 hasConceptScore W630074089C71924100 @default.
- W630074089 hasConceptScore W630074089C80461066 @default.
- W630074089 hasConceptScore W630074089C84393581 @default.
- W630074089 hasIssue "100" @default.
- W630074089 hasLocation W6300740891 @default.
- W630074089 hasLocation W6300740892 @default.
- W630074089 hasLocation W6300740893 @default.
- W630074089 hasLocation W6300740894 @default.
- W630074089 hasOpenAccess W630074089 @default.
- W630074089 hasPrimaryLocation W6300740891 @default.
- W630074089 hasRelatedWork W1869627629 @default.
- W630074089 hasRelatedWork W2011574657 @default.
- W630074089 hasRelatedWork W2048316791 @default.
- W630074089 hasRelatedWork W2095921129 @default.
- W630074089 hasRelatedWork W2113354544 @default.
- W630074089 hasRelatedWork W2121877854 @default.
- W630074089 hasRelatedWork W2125946186 @default.
- W630074089 hasRelatedWork W3127087054 @default.
- W630074089 hasRelatedWork W3137038939 @default.
- W630074089 hasRelatedWork W630074089 @default.
- W630074089 isParatext "false" @default.
- W630074089 isRetracted "false" @default.
- W630074089 magId "630074089" @default.
- W630074089 workType "article" @default.