Matches in SemOpenAlex for { <https://semopenalex.org/work/W630876743> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W630876743 abstract "Replacement heart valves offer substantial benefits to the patients with severe valvular heart disease. However, current prosthetic heart valves are still unable to meet the needs for more durable tissue valves and less thrombogenic mechanical valves. The aim of this research was to develop and evaluate a new generation heart valves made from a new shape-memory nitinol scaffold and a novel nanocomposite material known as polyhedral oligomeric silsesquioxanes poly(carbonate−urea) urethane (POSS-PCU). During the course of this research, the biomechanical properties of POSS-PCU nanocomposite were evaluated and compared to those of the materials currently used to fabricate bioprosthetic valves. Moreover, POSS-PCU nanocomposite was chemically engineered to improve its oxidative stability and minimise biodegradation. A novel artificial aortic valve was devised and transferred from a stented design into a semi-stented concept and then a retrievable and repositionable valve suitable for transcatheter implantation. The proposed surgical and transcatheter valves were manufactured by an innovative automated dip-coating technique. An industrial-scale automated dipping mechanism was designed to improve the reproducibility of polymeric valve leaflets with no need to suturing or adhesives. The POSS-PCU valves were assessed in vitro for their hydrodynamic performance in a test setup complying with ISO 5840 standards and were shown to have an advanced function compared to clinically available prosthetic valves. The transcatheter POSS-PCU valves (Triskele valves) were then subjected to preliminary acute animal study in ovine model and successfully implanted, retrieved and repositioned in orthotopic position with excellent valve function. The promising results from the in vitro functional tests and the preliminary in vivo study encourage the use of POSS-PCU nanocomposite material and superelastic nitinol wire-frame to develop a new generation transcatheter heart valves which can overcome the main limitations experienced with current solutions. Although further durability and long-term animal studies are required which are currently under investigation." @default.
- W630876743 created "2016-06-24" @default.
- W630876743 creator A5030119513 @default.
- W630876743 date "2015-01-28" @default.
- W630876743 modified "2023-09-27" @default.
- W630876743 title "Development of the next generation heart valves using a novel nanocomposite material" @default.
- W630876743 hasPublicationYear "2015" @default.
- W630876743 type Work @default.
- W630876743 sameAs 630876743 @default.
- W630876743 citedByCount "0" @default.
- W630876743 crossrefType "dissertation" @default.
- W630876743 hasAuthorship W630876743A5030119513 @default.
- W630876743 hasConcept C136229726 @default.
- W630876743 hasConcept C141071460 @default.
- W630876743 hasConcept C164705383 @default.
- W630876743 hasConcept C171250308 @default.
- W630876743 hasConcept C192562407 @default.
- W630876743 hasConcept C2776229121 @default.
- W630876743 hasConcept C2779736815 @default.
- W630876743 hasConcept C2780007028 @default.
- W630876743 hasConcept C2780026749 @default.
- W630876743 hasConcept C71924100 @default.
- W630876743 hasConcept C89429830 @default.
- W630876743 hasConcept C92880739 @default.
- W630876743 hasConceptScore W630876743C136229726 @default.
- W630876743 hasConceptScore W630876743C141071460 @default.
- W630876743 hasConceptScore W630876743C164705383 @default.
- W630876743 hasConceptScore W630876743C171250308 @default.
- W630876743 hasConceptScore W630876743C192562407 @default.
- W630876743 hasConceptScore W630876743C2776229121 @default.
- W630876743 hasConceptScore W630876743C2779736815 @default.
- W630876743 hasConceptScore W630876743C2780007028 @default.
- W630876743 hasConceptScore W630876743C2780026749 @default.
- W630876743 hasConceptScore W630876743C71924100 @default.
- W630876743 hasConceptScore W630876743C89429830 @default.
- W630876743 hasConceptScore W630876743C92880739 @default.
- W630876743 hasLocation W6308767431 @default.
- W630876743 hasOpenAccess W630876743 @default.
- W630876743 hasPrimaryLocation W6308767431 @default.
- W630876743 hasRelatedWork W1963923860 @default.
- W630876743 hasRelatedWork W2050369129 @default.
- W630876743 hasRelatedWork W2054747826 @default.
- W630876743 hasRelatedWork W2095156095 @default.
- W630876743 hasRelatedWork W2096303910 @default.
- W630876743 hasRelatedWork W2107926535 @default.
- W630876743 hasRelatedWork W2149580930 @default.
- W630876743 hasRelatedWork W2161256499 @default.
- W630876743 hasRelatedWork W2179857494 @default.
- W630876743 hasRelatedWork W2209695549 @default.
- W630876743 hasRelatedWork W2343044889 @default.
- W630876743 hasRelatedWork W2387666996 @default.
- W630876743 hasRelatedWork W2390896866 @default.
- W630876743 hasRelatedWork W2567551266 @default.
- W630876743 hasRelatedWork W2740607701 @default.
- W630876743 hasRelatedWork W2806673964 @default.
- W630876743 hasRelatedWork W2862447479 @default.
- W630876743 hasRelatedWork W3006400411 @default.
- W630876743 hasRelatedWork W3114347223 @default.
- W630876743 hasRelatedWork W2536990966 @default.
- W630876743 isParatext "false" @default.
- W630876743 isRetracted "false" @default.
- W630876743 magId "630876743" @default.
- W630876743 workType "dissertation" @default.