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- W63097777 abstract "This thesis describes the development and preliminary application ofmethods for performing simultaneous electroencephalography (EEG) andnear-infrared (NIR) imaging of the brain. The simultaneous application ofEEG and NIR imaging has many benefits because of the complementarynature of the two modalities, and has significant potential in the study of therelationship between neuronal activity and cerebral haemodynamics.This work goes beyond previous experiments which have combined EEGand limited-channel near-infrared spectroscopy by designing andimplementing an arrangement which allows dense near-infrared opticaltopography and EEG to be performed over the same cortical area, with assimple an application method as possible. These application methods aredescribed in detail, as is their extensive testing using novel dual-modalityphantoms and an in-vivo EEG-NIR imaging experiment in a healthy adult.These methods are subsequently applied to the study of neonates in theclinical environment. An intricate EEG-NIR imaging experiment isdesigned and implemented in an investigation of functional activation in thehealthy neonatal visual cortex. This series of experiments also acts as afurther test of the suitability of our EEG-NIR imaging methods for clinicalapplication. The results of these experiments are presented.The EEG-NIR imaging arrangement is then applied to four neurologicallydamaged infants in the neonatal intensive care unit, each of whom had beendiagnosed with seizures. The results of these studies are presented, and apotentially significant haemodynamic feature, which is not present in agematchedcontrols, is identified. The importance and physiologicalimplications of our findings are discussed, as is the suitability of a combinedEEG and NIR imaging approach to the study and monitoring of neonatalbrain injury." @default.
- W63097777 created "2016-06-24" @default.
- W63097777 creator A5050190425 @default.
- W63097777 date "2010-12-28" @default.
- W63097777 modified "2023-09-26" @default.
- W63097777 title "Development of simultaneous electroencephalography and near-infrared optical topography for applications to neurovascular coupling and neonatal seizures" @default.
- W63097777 hasPublicationYear "2010" @default.
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