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- W631314132 abstract "An eight-year old dog who was suffering from two big mass between L5-L6 and T7-T8 was referred to a private hospital and thoracic radiographes and ultrasonography showed no metastasis. After mastectomy, histopathology results revealed Cribriform Carcinoma. Tumor cells arranged in cribriform, solid with comedo and micropapillary and also subdivided into Elston Grade II. One year after surgery the owner was asked about the health status of his animal and she was well. Immunohistochemical studies indicate positive expression of P53 and Ki67 and negative Her2. Cribriform Carcinoma is common in cat and rare in dog and this is the first report of Cribriform Carcinoma in Iran. Introduction Mammary neoplasms in dogs are 2nd in frequency after skin tumors and they are the most common types of tumors in the bitch. According to the histological diagnosis, between 41 and 53% of the mammary tumors that occur in the bitch are considered malignant(Misdorp 2002). According WHO classification, Cribriform carcinoma is one kind of simple carcinoma and is common in the cat. Cribriform carcinomas are basically solid carcinoma with small apertures like a sieve. Case History An eight-year old dog who was suffering from two big mass between L5-L6 and T7-T8 was referred to a private hospital and thoracic radiographes and ultrasonography showed no metastases. The samples which were sent to pathology lab had many cavities in different size and contained milky fluid, fixed in 10% formalin buffered, processed by routine methods, embedded in paraffin wax, sectioned at 5 micron and stained with Haematoxilin and Eosin (H&E). Histological grading was performed on H&E stained section, according to Elston & Ellis grading method. Immunohistochemical staining was performed according to the standard avidin-biotin peroxidase complex method for P53 (monoclonal anti-human clone DO7), Ki67 ( monoclonal anti-human antibody clone MIB1, dilution I:100) and c-erbB2(polyclonal rabbit anti-human antibody her2/neu, dilution 1:100)." @default.
- W631314132 created "2016-06-24" @default.
- W631314132 creator A5012266362 @default.
- W631314132 date "2008-10-29" @default.
- W631314132 modified "2023-09-26" @default.
- W631314132 title "Cribriform carcinoma in a dog" @default.
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