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- W631495903 abstract "A new family of ruthenium(II)-arene complexes with naphthalimide functionalized N,O- and N,N-chelating ligands of the general formula [Ru(η6-p-cymene)Cl(L)] (2b–4b) (where: L = 4-[N-(2-((2-hydroxy-5-Br-phenyl)methyl imino)ethyl)]-N-butyl-1,8-naphthalimide (2a), 4-[N-(2-((2-hydroxy-5-Cl-phenyl)methyl imino)ethyl)]-N-butyl-1,8-naphthalimide (3a), and N-butyl-4-[N-(2-((2-hydroxy-5-NO2-phenyl)methylimino)ethyl)]-N-butyl-1,8-naphthalimide (4a), and [Ru(η6-p-cymene) Cl(L′)]Cl (8b–9b) (where L′ = N-(2,2′-dipyridylaminoethyl)-1,8-naphthalimide (8a) and N-(2,2′-dipyridylaminopropyl)-1,8-naphthalimide (9a) have been synthesized and characterized. The in vitro cytotoxic activities of the ligands (2a, 9a) and the complexes (2b–4b, and 8b–9b) have been evaluated against the human melanoma skin cancer (CRL7687) and normal noncancerous (CA-M75) cell lines. All the compounds exhibit potent cytotoxic activities with IC50 values of ∼1 μM or less but displayed variable selectivity. The compounds with N,O-ligands were found to be less selective than those containing N,N-chelating ligands. Notably, complex 9b displayed the highest selectivity towards cancer cells over health cells. The interactions of the compounds with calf thymus DNA (CT-DNA) have also been investigated by UV–Vis and fluorescence spectra, ethidium bromide displacement assay and gel electrophoretic studies, which revealed that the compounds bind to CT-DNA moderately presumably through an intercalative mode." @default.
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- W631495903 date "2015-08-01" @default.
- W631495903 modified "2023-10-10" @default.
- W631495903 title "Ruthenium(II)-arene complexes with naphthalimide-tagged N,O- and N,N-chelating ligands: Synthesis and biological evaluation" @default.
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- W631495903 doi "https://doi.org/10.1016/j.ica.2015.05.025" @default.
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