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- W63165746 abstract "Thirty-six weanling male SD rats were randomly assigned to one of four treatment groups. SE rats received 4.0 ppm Se as sodium selenite in their drinking water, 15MO rats received 15 ppm Mo as sodium molybdate, 45MO rats received 45 ppm Mo, and CON rats received distilled water. Beginning on the same day as provision of the above solutions, methylbenzylnitrosamine (MBN) was administered intragastrically in 10% ethanol twice per week for 5 weeks at a dose of 2.5 mg/kg; this was followed by a 12-week latency period. Following this, blood was withdrawn and heart, lungs, liver, spleen, kidneys, testes, tibia, muscle, brain and esophagus were excised. The esophagus was examined for MBN-induced lesions using dissecting and light microscopes. Tissues were analyzed for Cu, Zn, Fe, Mn, Se and Mo. Most rats had precancerous lesions and all rats had papillomas. There were no significant differences among the four treatment groups in the numbers of precancerous lesions or gross papillomas per rat. The SE group had significantly fewer carcinomas than the other groups. The SE rats exhibited a number of significant differences in tissue trace metal concentrations, in particular they had higher Fe concentrations in heart, kidney, liver and spleen. It ismore » possible that the anticarcinogenic activity of Se is related to its effects of the metabolism of other essential trace elements.« less" @default.
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- W63165746 date "1986-03-01" @default.
- W63165746 modified "2023-09-26" @default.
- W63165746 title "Effects of selenium and molybdenum on esophageal tumors and tissue trace metals" @default.
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