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• W632348632 abstract "Abstract The mechanisms behind the shortening-induced force depression commonly observed in skeletal muscles remain unclear, but have been associated with sarcomere length non-uniformity and/or crossbridge inhibition. The purpose of this study was twofold: (i) to evaluate if force depression is present in isolated single sarcomeres, a preparation that eliminates sarcomere length non-uniformities and (ii) to evaluate if force depression is inhibited when single sarcomeres are activated with MgADP, which biases crossbridges into a strongly-bound state. Single sarcomeres (n = 16) were isolated from rabbit psoas myofibrils using two micro-needles (one compliant, one rigid), piercing the sarcomere externally adjacent to the Z-lines. The sarcomeres were contracted isometrically and subsequently shortened, in both Ca 2+ - and MgADP-activating solutions. Shortening in Ca 2+ -activated samples resulted in a 27.44 ± 9.04% force depression when compared to isometric contractions produced at similar final sarcomere lengths (P < 0.001). There was no force depression in MgADP-activated sarcomeres (force depression = −1.79 ± 9.69%, P = 0.435). These results suggest that force depression is a sarcomeric property and that is associated with an inhibition of myosin-actin interactions." @default.
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• W632348632 date "2015-06-03" @default.
• W632348632 modified "2023-10-01" @default.
• W632348632 title "Residual force depression in single sarcomeres is abolished by MgADP-induced activation" @default.
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• W632348632 doi "https://doi.org/10.1038/srep10555" @default.
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