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- W632468597 abstract "The ability to switch from yeast to hyphal growth is essential for virulence in Candida albicans. The cell surface is the initial point of contact between the fungus and the host. In this work, a free-gel proteomic strategy based on tryptic digestion of live yeast and hyphae cells and protein identification using LC-MS/MS methodology was used to identify cell surface proteins. Using this strategy, a total of 943 proteins were identified, of which 438 were in yeast and 928 were in hyphae. Of these proteins, 79 were closely related to the organization and biogenesis of the cell wall, including 28 GPI-anchored proteins, such as Hyr1 and Sod5 which were detected exclusively in hyphae, and Als2 and Sap10which were detected only in yeast. A group of 17 proteins of unknown function were subsequently studied by analysis of the corresponding deletion mutants. We found that four new proteins, Pst3, Tos1, Orf19.3060 and Orf19.5352 are involved in cell wall integrity and in C. albicans' engulfment by macrophages. Moreover, the putative NADH-ubiquinone-related proteins, Ali1, Mci4, Orf19.287 and Orf19.7590, are also involved in osmotic and oxidative resistance, yeast to hypha transition and the ability to damage and invade oral epithelial cells. This article is part of a Special Issue entitled: HUPO 2014." @default.
- W632468597 created "2016-06-24" @default.
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- W632468597 date "2015-09-01" @default.
- W632468597 modified "2023-09-30" @default.
- W632468597 title "Candida albicans cell shaving uncovers new proteins involved in cell wall integrity, yeast to hypha transition, stress response and host–pathogen interaction" @default.
- W632468597 cites W1500387969 @default.
- W632468597 cites W1507738894 @default.
- W632468597 cites W1535701124 @default.
- W632468597 cites W1667261212 @default.
- W632468597 cites W1839486704 @default.
- W632468597 cites W1847096287 @default.
- W632468597 cites W1966516361 @default.
- W632468597 cites W1967096312 @default.
- W632468597 cites W1968911442 @default.
- W632468597 cites W1970499587 @default.
- W632468597 cites W1978958698 @default.
- W632468597 cites W1988620877 @default.
- W632468597 cites W1998246499 @default.
- W632468597 cites W2000752062 @default.
- W632468597 cites W2002220100 @default.
- W632468597 cites W2002221873 @default.
- W632468597 cites W2002379595 @default.
- W632468597 cites W2003199362 @default.
- W632468597 cites W2004591077 @default.
- W632468597 cites W2006386982 @default.
- W632468597 cites W2022215482 @default.
- W632468597 cites W2022948162 @default.
- W632468597 cites W2027249101 @default.
- W632468597 cites W2030616401 @default.
- W632468597 cites W2031695033 @default.
- W632468597 cites W2032984007 @default.
- W632468597 cites W2034674073 @default.
- W632468597 cites W2041611856 @default.
- W632468597 cites W2041675379 @default.
- W632468597 cites W2044796416 @default.
- W632468597 cites W2053195919 @default.
- W632468597 cites W2053943711 @default.
- W632468597 cites W2060721894 @default.
- W632468597 cites W2069731430 @default.
- W632468597 cites W2073575059 @default.
- W632468597 cites W2079553804 @default.
- W632468597 cites W2083666225 @default.
- W632468597 cites W2084700329 @default.
- W632468597 cites W2094831794 @default.
- W632468597 cites W2096037926 @default.
- W632468597 cites W2098166370 @default.
- W632468597 cites W2098979038 @default.
- W632468597 cites W2101877292 @default.
- W632468597 cites W2106451562 @default.
- W632468597 cites W2107490735 @default.
- W632468597 cites W2107580083 @default.
- W632468597 cites W2109110922 @default.
- W632468597 cites W2109228421 @default.
- W632468597 cites W2110641885 @default.
- W632468597 cites W2111728249 @default.
- W632468597 cites W2111818968 @default.
- W632468597 cites W2113880496 @default.
- W632468597 cites W2114164442 @default.
- W632468597 cites W2116830493 @default.
- W632468597 cites W2117903782 @default.
- W632468597 cites W2122567752 @default.
- W632468597 cites W2122917566 @default.
- W632468597 cites W2124008198 @default.
- W632468597 cites W2126476096 @default.
- W632468597 cites W2128672233 @default.
- W632468597 cites W2129062885 @default.
- W632468597 cites W2134152581 @default.
- W632468597 cites W2134276987 @default.
- W632468597 cites W2135143690 @default.
- W632468597 cites W2135386119 @default.
- W632468597 cites W2135741099 @default.
- W632468597 cites W2135843205 @default.
- W632468597 cites W2137626431 @default.
- W632468597 cites W2137959581 @default.
- W632468597 cites W2139307267 @default.
- W632468597 cites W2144035662 @default.
- W632468597 cites W2148087906 @default.
- W632468597 cites W2150543962 @default.
- W632468597 cites W2158528341 @default.
- W632468597 cites W2161575072 @default.
- W632468597 cites W2163812071 @default.
- W632468597 cites W2164865202 @default.
- W632468597 cites W2170120355 @default.
- W632468597 cites W2170908195 @default.
- W632468597 cites W2761946910 @default.
- W632468597 doi "https://doi.org/10.1016/j.jprot.2015.06.006" @default.
- W632468597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4721921" @default.
- W632468597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26087349" @default.
- W632468597 hasPublicationYear "2015" @default.
- W632468597 type Work @default.