Matches in SemOpenAlex for { <https://semopenalex.org/work/W632608725> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W632608725 endingPage "127" @default.
- W632608725 startingPage "122" @default.
- W632608725 abstract "Bone tissue engineering (TE) is a multidisciplinary field of science focusing on the healing of large bone defects [1]. One of the most promising bone TE approaches is the use of stem cells in combination with three-dimensional (3D) biomaterials (= scaffolds) and soluble signalling molecules to support osteogenic (bone forming) processes [1]. For the evaluation of the bone forming capacity of specific stem cell – biomaterial combinations (i.e. TE constructs), both in vitro biomaterial screening/selection and in vivo assessment are required. To date, existing bone TE strategies suffer from unpredictable and qualitatively inferior results, thus hampering clinical translation [2, 3]. This low repeatability or lack of robustness is caused by widely variable material and cell characteristics [4], the latter being also influenced by donor-specificities [5-8]. Hence, the optimal bone scaffold structure is still under debate, and it becomes more and more doubtful if it can be found by the present approaches or that it even exists. The latter reasoning will force biomaterial development to customization. In this study, initial indications for materialand donor-variability were generated, as well as for the influence of the implantation site on the bone forming capacity of human periosteal derived cells (hPDCs) on CaP-collagen scaffolds. Because of the destructive, labor intensive and costly character (i.e. in terms of time and resources) of histomorphometry, and the related loss of information due to restricted sectioning orientations and limited depth resolution, high-resolution X-ray microfocus computed tomography (microCT) was used for in-depth and 3D initial material and explant characterisation. In this way, the variability in initial material properties, donor-specificity, as well as the effect of the implantation site on the scaffold structure was assessed." @default.
- W632608725 created "2016-06-24" @default.
- W632608725 creator A5003676589 @default.
- W632608725 creator A5030220964 @default.
- W632608725 creator A5041969019 @default.
- W632608725 creator A5050555039 @default.
- W632608725 creator A5059823367 @default.
- W632608725 creator A5070263200 @default.
- W632608725 creator A5083161862 @default.
- W632608725 creator A5089082483 @default.
- W632608725 creator A5090307028 @default.
- W632608725 date "2013-04-01" @default.
- W632608725 modified "2023-09-27" @default.
- W632608725 title "Micro-CT evaluation of the effect of material, donor and implantation site variability on the bone forming capacity of progenitor cell/CaP-collagen constructs implanted ectopically in nude mice" @default.
- W632608725 cites W1162928621 @default.
- W632608725 cites W1970127412 @default.
- W632608725 cites W1973898642 @default.
- W632608725 cites W1974610140 @default.
- W632608725 cites W2001733628 @default.
- W632608725 cites W2004982583 @default.
- W632608725 cites W2080401999 @default.
- W632608725 cites W2164112925 @default.
- W632608725 cites W2491699159 @default.
- W632608725 hasPublicationYear "2013" @default.
- W632608725 type Work @default.
- W632608725 sameAs 632608725 @default.
- W632608725 citedByCount "0" @default.
- W632608725 crossrefType "journal-article" @default.
- W632608725 hasAuthorship W632608725A5003676589 @default.
- W632608725 hasAuthorship W632608725A5030220964 @default.
- W632608725 hasAuthorship W632608725A5041969019 @default.
- W632608725 hasAuthorship W632608725A5050555039 @default.
- W632608725 hasAuthorship W632608725A5059823367 @default.
- W632608725 hasAuthorship W632608725A5070263200 @default.
- W632608725 hasAuthorship W632608725A5083161862 @default.
- W632608725 hasAuthorship W632608725A5089082483 @default.
- W632608725 hasAuthorship W632608725A5090307028 @default.
- W632608725 hasConcept C127313418 @default.
- W632608725 hasConcept C136229726 @default.
- W632608725 hasConcept C192562407 @default.
- W632608725 hasConcept C201750760 @default.
- W632608725 hasConcept C2778414984 @default.
- W632608725 hasConcept C28328180 @default.
- W632608725 hasConcept C3020199158 @default.
- W632608725 hasConcept C49892992 @default.
- W632608725 hasConcept C62649853 @default.
- W632608725 hasConcept C71924100 @default.
- W632608725 hasConcept C86803240 @default.
- W632608725 hasConcept C89429830 @default.
- W632608725 hasConcept C95444343 @default.
- W632608725 hasConceptScore W632608725C127313418 @default.
- W632608725 hasConceptScore W632608725C136229726 @default.
- W632608725 hasConceptScore W632608725C192562407 @default.
- W632608725 hasConceptScore W632608725C201750760 @default.
- W632608725 hasConceptScore W632608725C2778414984 @default.
- W632608725 hasConceptScore W632608725C28328180 @default.
- W632608725 hasConceptScore W632608725C3020199158 @default.
- W632608725 hasConceptScore W632608725C49892992 @default.
- W632608725 hasConceptScore W632608725C62649853 @default.
- W632608725 hasConceptScore W632608725C71924100 @default.
- W632608725 hasConceptScore W632608725C86803240 @default.
- W632608725 hasConceptScore W632608725C89429830 @default.
- W632608725 hasConceptScore W632608725C95444343 @default.
- W632608725 hasLocation W6326087251 @default.
- W632608725 hasOpenAccess W632608725 @default.
- W632608725 hasPrimaryLocation W6326087251 @default.
- W632608725 hasRelatedWork W1570204784 @default.
- W632608725 hasRelatedWork W158043483 @default.
- W632608725 hasRelatedWork W1585104643 @default.
- W632608725 hasRelatedWork W1983217137 @default.
- W632608725 hasRelatedWork W2015639342 @default.
- W632608725 hasRelatedWork W2157858709 @default.
- W632608725 hasRelatedWork W2190909531 @default.
- W632608725 hasRelatedWork W2402714262 @default.
- W632608725 hasRelatedWork W2532295919 @default.
- W632608725 hasRelatedWork W2544456086 @default.
- W632608725 hasRelatedWork W2765530452 @default.
- W632608725 hasRelatedWork W2792484935 @default.
- W632608725 hasRelatedWork W2801700088 @default.
- W632608725 hasRelatedWork W2968068940 @default.
- W632608725 hasRelatedWork W2981841141 @default.
- W632608725 hasRelatedWork W3000600814 @default.
- W632608725 hasRelatedWork W3024382855 @default.
- W632608725 hasRelatedWork W3033436240 @default.
- W632608725 hasRelatedWork W311399783 @default.
- W632608725 hasRelatedWork W2612853274 @default.
- W632608725 isParatext "false" @default.
- W632608725 isRetracted "false" @default.
- W632608725 magId "632608725" @default.
- W632608725 workType "article" @default.