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- W63277029 abstract "The cytochrome P450 (CYP) family contains 57 enzymes in humans. The activity of CYPs against xenobiotics is a primary consideration in drug optimization efforts. Here we describe a series of bioluminescent assays that enable the rapid profiling of CYP activity against compound collections. The assays employ a coupled-enzyme format where firefly luciferase is used to measure CYP enzyme activity through metabolism of pro-luciferase substrates." @default.
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- W63277029 date "2013-01-01" @default.
- W63277029 modified "2023-10-16" @default.
- W63277029 title "Bioluminescent Assays for Cytochrome P450 Enzymes" @default.
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- W63277029 doi "https://doi.org/10.1007/978-1-62703-321-3_1" @default.
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