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• W63298 abstract "Event Abstract Back to Event Event Related Oscillations in Alzheimer’s Disease Gorsev Yener1*, B. Güntekin2, E. Saatçi2 and Erol Basar2 1 Dokuz Eylül University, Türkiye 2 Faculty of Science and Letters,Istanbul Kultur University, Cognition and Complex Systems Research Unit, Türkiye Event-related oscillations are among new popular techniques for assessing cognitive processes. Peak amplitudes, theta oscillatory phase locking and coherences of event related oscillations were evaluated in 22 mild probable AD subjects according to NINCDS-ADRDA criteria (11 non-treated, 11 treated by cholinesterase inhibitors), and 20 healthy elderly controls were analyzed by using the conventional visual oddball paradigm. At F3 location, theta responses of healthy subjects were phase locked to stimulation and theta oscillatory responses of non-treated Alzheimer patients showed weaker phase-locking, i.e. average of z-transformed means of correlation coefficients between single trials. The phase-locking of theta oscillations at F3 in the treated patients is as strong as the control subjects. Peak amplitudes at mid- and left central regions, (Cz, C3) showed significant differences in delta frequency range, being higher in controls than either AD groups (F (9.120)=2.228; p=0.022). Our findings imply that the theta responses at F3 location are highly unstable in comparison to F4 in non-treated mild AD patients and cholinergic agents may modulate event-related theta oscillatory activities in the frontal regions, yet delta oscillatory responses at central locations are highly instable in mild probable AD patients regardless of treatment. Coherences revealed more extensive changes in AD patients different than normal controls. At frontal electrodes, where the most prominent changes were expected, alpha, theta and delta coherences were significantly lower in either AD groups. As a conclusion, our study once more supports the efficacy of the oscillatory responses for understanding brain dynamics in AD. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Türkiye, 1 Sep - 5 Sep, 2008. Presentation Type: Oral Presentation Topic: Symposium 9: Cognitive electrophysiology in neuropsychriatric disorders Citation: Yener G, Güntekin B, Saatçi E and Basar E (2008). Event Related Oscillations in Alzheimer’s Disease. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.043 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Nov 2008; Published Online: 27 Nov 2008. * Correspondence: Gorsev Yener, Dokuz Eylül University, Izmir, Türkiye, gorsev.yener@deu.edu.tr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gorsev Yener B. Güntekin E. Saatçi Erol Basar Google Gorsev Yener B. Güntekin E. Saatçi Erol Basar Google Scholar Gorsev Yener B. Güntekin E. Saatçi Erol Basar PubMed Gorsev Yener B. Güntekin E. Saatçi Erol Basar Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W63298 title "Event Related Oscillations in Alzheimer’s Disease" @default.
• W63298 doi "https://doi.org/10.3389/conf.neuro.09.2009.01.043" @default.
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