FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W63350998> ?p ?o ?g. }

• W63350998 endingPage "6" @default.
• W63350998 startingPage "153" @default.
• W63350998 abstract "Chicken flavored glycerinated gelatin candy-based lozenges and oil-in-water emulsions of metronidazole benzoate were prepared for veterinary use. The stability and dissolution of the lozenges and emulsions were investigated via a high-pressure (performance) liquid chromatography (HPLC) assay. The separation and quantitation of metronidazole benzoate were achieved on a Phenomenex IB-SIL 5 C8 column (250 x 4.6 mm,id) at ambient temperature, with a 55:45 v/v pH 7.0 phosphate buffer-acetonitrile mobile phase at a flow rate of 1.0 mL/min. Tinidazole was used as the internal standard. A sample of metronidazole benzoate form the lozenge and emulsion was prepared for assay by dissolving one lozenge or 1g of the emulsion in 50:50 v/v methanol-water solution, and that sample was filtered through a 0.2 micrometer membrane filter before assay. The chromatogram was monitored with ultraviolet detection at 230 nm. The HPLC separation of metronidazole benzoate was achieved in less than 10 minutes; sensitivity was in the rage of 10 ng/mL. This method can be used to separate metronidazole and benzoic acid, which are degradation products of metronidazole benzoate, and demonstrated linearity for metronidazole benzoate in the range of 0.01 to 100 micrograms/mL. Accuracy and precision were less than 1.0% and less than 0.54%, repectively. The limit of quantitation was 10 ng/mL, and the limit of detection was 0.01 ng/mL, based on a signal-to-noise ratio of 3 and a 20 microliter injection. The recoveries of metronidazole benzoate from the lozenge and emulsion were 98% +/- 4% and 99% +/- 2%, respectively. Stability testing of the new formulations was performed at ambient temperature and at 4 deg C. Dissolution testing used the USP paddle method at 37 deg C and 100 rpm in simulated gastric fluid without pepsin. Both formulations were stable at ambient temperature and at 4 deg C. Metronidazole benzoate is completely released from the lozenge and emulsion formulations based on dissolution T50% values of 4.2 and 24 minutes and T90% values of 12.8 and 83 minutes, repectively." @default.
• W63350998 created "2016-06-24" @default.
• W63350998 creator A5027363073 @default.
• W63350998 creator A5028890529 @default.
• W63350998 creator A5031815634 @default.
• W63350998 date "2001-03-01" @default.
• W63350998 modified "2023-09-23" @default.
• W63350998 title "Stability and dissolution of lozenge and emulsion formulations of metronidazole benzoate." @default.
• W63350998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23981838" @default.
• W63350998 hasPublicationYear "2001" @default.
• W63350998 type Work @default.
• W63350998 sameAs 63350998 @default.
• W63350998 citedByCount "0" @default.
• W63350998 crossrefType "journal-article" @default.
• W63350998 hasAuthorship W63350998A5027363073 @default.
• W63350998 hasAuthorship W63350998A5028890529 @default.
• W63350998 hasAuthorship W63350998A5031815634 @default.
• W63350998 hasConcept C119128265 @default.
• W63350998 hasConcept C178790620 @default.
• W63350998 hasConcept C179998833 @default.
• W63350998 hasConcept C185592680 @default.
• W63350998 hasConcept C2777396551 @default.
• W63350998 hasConcept C2778123984 @default.
• W63350998 hasConcept C2780626017 @default.
• W63350998 hasConcept C43617362 @default.
• W63350998 hasConcept C501593827 @default.
• W63350998 hasConcept C55493867 @default.
• W63350998 hasConcept C88380143 @default.
• W63350998 hasConceptScore W63350998C119128265 @default.
• W63350998 hasConceptScore W63350998C178790620 @default.
• W63350998 hasConceptScore W63350998C179998833 @default.
• W63350998 hasConceptScore W63350998C185592680 @default.
• W63350998 hasConceptScore W63350998C2777396551 @default.
• W63350998 hasConceptScore W63350998C2778123984 @default.
• W63350998 hasConceptScore W63350998C2780626017 @default.
• W63350998 hasConceptScore W63350998C43617362 @default.
• W63350998 hasConceptScore W63350998C501593827 @default.
• W63350998 hasConceptScore W63350998C55493867 @default.
• W63350998 hasConceptScore W63350998C88380143 @default.
• W63350998 hasIssue "2" @default.
• W63350998 hasLocation W633509981 @default.
• W63350998 hasOpenAccess W63350998 @default.
• W63350998 hasPrimaryLocation W633509981 @default.
• W63350998 hasRelatedWork W1913148260 @default.
• W63350998 hasRelatedWork W1998279148 @default.
• W63350998 hasRelatedWork W2013299392 @default.
• W63350998 hasRelatedWork W2018955441 @default.
• W63350998 hasRelatedWork W2032191029 @default.
• W63350998 hasRelatedWork W2080191601 @default.
• W63350998 hasRelatedWork W233519783 @default.
• W63350998 hasRelatedWork W2355110517 @default.
• W63350998 hasRelatedWork W3029450219 @default.
• W63350998 hasRelatedWork W3085245795 @default.
• W63350998 hasVolume "5" @default.
• W63350998 isParatext "false" @default.
• W63350998 isRetracted "false" @default.
• W63350998 magId "63350998" @default.
• W63350998 workType "article" @default.