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- W63354846 abstract "Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive inflammation with massive infiltration of leukocytes into the synovium of multiple joints. Although monocyte/macrophage infiltration is a prominent feature and correlated with disease severity, the exactly role of monocytes in the induction phase of joint inflammation is unknown. Using two-photon microscopy, we tested whether monocytes regulate the recruitment of neutrophils during K/B×N serum induced arthritis. We examined neutrophil trafficking dynamics in vivo in LysM-GFP mice using the established i.v. transfer model and a modified in which serum was injected subcutaneously (s.c.) into the footpad. The s.c. model had several advantages including: more synchronized cell trafficking behaviors, shorter disease course and focused inflammation in the affected limb. We found that clodronate-liposome depletion of monocytes impaired neutrophil recruitment in our model at two separate steps. First, transendothelial cell migration was inhibited significantly, leaving many neutrophils stranded along the endothelial surface. Moreover, the cells that managed to extravasate showed defective chemotaxis and localization to the joint. Our results suggest that monocytes serve as key mediators of neutrophil extravasation and may play a second role in controlling the local tissue distribution of neutrophils during arthritis. Key words: Arthritis, Monocyte, Neutrophil, two photon microscopy" @default.
- W63354846 created "2016-06-24" @default.
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- W63354846 date "2010-04-01" @default.
- W63354846 modified "2023-09-27" @default.
- W63354846 title "In vivo imaging of monocyte mediated neutrophil extravasation during acute arthritis (140.6)" @default.
- W63354846 doi "https://doi.org/10.4049/jimmunol.184.supp.140.6" @default.
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