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• W633656421 abstract "Although yeasts of the genus Candida are part of the normal human oral microbiota, in cancer patients they may be associated with invasive fungal infections. Antineoplastic therapy, with its adverse side effects, increases the likelihood of such infection. One of the important virulence factors is the capacity of yeast cells to adhere to the surface of medical devices inserted into patients. In this study, we tested the in vitro adhesive and film-growing capacity of four Candida albicans samples, isolated before and during chemotherapy from the oral cavity of a patient with adenocarcinoma. Adherence to the orotracheal tube (OTT) and biofilm production were assessed spectrophotometrically and the amount of film growth was estimated by measuring fungal metabolism. Also, the frequency and size of germ tubes were evaluated. The results showed a significant increase in the germ tube size of C. albicans and also an increase in yeast adherence to the OTT after the start of chemotherapy with mitoxantrone. Keywords: Virulence. Adherence. Candida spp. Antineoplastic therapy. RESUMOAumento da virulencia de Candida albicans apos tratamento de quimioterapia Embora as leveduras do genero Candida pertencam a microbiota humana oral normal, em pacientes com câncer a sua presenca pode estar associada a infeccoes fungicas invasivas. O tratamento quimioterapico, com seus efeitos colaterais, aumenta as chances desta possibilidade. Um dos principais fatores de virulencia consiste na capacidade das leveduras de se aderirem a superficie de instrumentos medicos inseridos nos pacientes. O presente estudo avaliou a capacidade in vitro de quatro isolados de Candida albicans, obtidos antes e apos o inicio da quimioterapia de um paciente com adenocarcinoma. Estudos de adesao a tubo endotraqueal; producao de biofilme e quantificacao por meio do metabolismo fungico pelo XTT; frequencia e tamanho de tubos germinativos foram realizados. Os resultados demonstraram aumento significante no tamanho do tubo germinativo, assim como o aumento da aderencia dessas leveduras ao tubo endotraqueal apos o inicio da quimioterapia com mitoxantrone. Palavras-chave: Virulencia. Aderencia. Candida spp. Tratamento quimioterapico." @default.
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• W633656421 date "2011-01-11" @default.
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• W633656421 title "Increased virulence of Candida albicans after antineoplastic chemotherapy" @default.
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