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- W63368690 abstract "The use of intensive chemotherapy regimens has led to considerable improvement in the prognosis of adult acute lymphoblastic leukemia (ALL), but the results are still unsatisfactory with only about 30% of patients having probability of remaining continuously disease free [1,2]. A further intensification of the induction and consolidation regimens is limited by hematopoietic toxicity, and therefore the use of recently available recombinant human growth factors [3] should be considered. The studies on the bone marrow cell kinetics after GM-CSF administration [3,4] suggest that the 48-to 96-h period after discontinuing GM-CSF represents a period of partial refractoriness of hematopoietic progenitors to cell cycle dependent cytostatics." @default.
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- W63368690 date "1994-01-01" @default.
- W63368690 modified "2023-09-25" @default.
- W63368690 title "Efficacy of an Original Cell Kinetics Based Chemotherapy Regimen Using rHU GM-CSF for Induction and Consolidation Treatment of ALL. Preliminary Analysis" @default.
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