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- W634172027 abstract "Investigation of the biological basis of anxiety is hampered by the lack of an appropriate animal model for research purposes. There are no known drugs that cause anxiety in laboratory animals. Pentylenetetrazol (PTZ) produces intense anxiety in human volunteers (Rodin, 1958; Rodin and Calhoun, 1970). Therefore, it was the major objective of this dissertation to test the hypothesis that the discriminative stimulus produced by PTZ in the rat was related to its anxiogenic action in man. It was also an objective to suggest the neurochemical basis for the discriminative stimulus property of PTZ through appropriate drug interactions. In an operant procedure of lever pressing on a FR 10 schedule of food reinforcement, male hooded rats were trained to respond with a lever on one side of a food cup 15 min following a 20 mg/kg PTZ injection and to respond with a lever on the alternate side 15 min following a 1 ml/kg saline injection. All of the rats learned this discrimination reliably in a mean of 30 training sessions. The discriminative stimulus produced by PTZ was dose- and time-dependent. The anxiogenic stimulants cocaine, R05-3663 and strychnine generalized to the PTZ discriminative stimulus whereas yohimbine partially generalized." @default.
- W634172027 created "2016-06-24" @default.
- W634172027 creator A5074217366 @default.
- W634172027 date "2020-05-26" @default.
- W634172027 modified "2023-10-14" @default.
- W634172027 title "THE ANXIOMIMETIC PROPERTIES OF PENTYLENETETRAZOL IN THE RAT" @default.
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