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- W634603280 abstract "Madhu, Malav. M.S., Department of Pharmacology and Toxicology, Wright State University, 2009. Impact of Diabetes on ACE/ACE2 Balance and Angiotensin II Type 1 Receptor Expression in db/db Diabetic Mice. Alterations in the renin-angiotensin system (RAS) are considered to be crucial for the development of diabetic complications like hypertension and nephropathy. Our previous work demonstrated role of AT1 receptors (AT1R) in the development of hypertension in db/db diabetic mice. The aim of this study was to test the hypothesis that there is upregulation of renal AT1R and imbalance in renal ACE/ACE2 homeostasis in db/db mice. In addition, we hypothesize that treatment with an anti-hyperglycemic or an AT1R blocker will correct this imbalance. Five week old control and db/db mice were housed in metabolic cages for 24 hour collection of urine. At early age of 5 weeks, db/db mice were obese and hyperglycemic. Urinary albumin excretion was also significantly high in db/db mice. Changes in RAS were evaluated using enzyme activities, western blots and immunohistochemistry. There was a significant increase in urinary ACE2 activity and ACE2 content in db/db mice at 5 weeks. There was a significant increase in plasma ACE activity and Ang II content in db/db mice compared to controls at 8 weeks. Western blot analysis showed significant increase in AT1R protein expression in 8, 18 and 31 week db/db mice compared to controls. There was upregulation of ACE2 and down-regulation of ACE in kidney to compensate the effects of high plasma Ang II. To study the effect of reduction in blood glucose and AT1R blockade, mice were treated" @default.
- W634603280 created "2016-06-24" @default.
- W634603280 creator A5049984573 @default.
- W634603280 date "2009-01-01" @default.
- W634603280 modified "2023-09-27" @default.
- W634603280 title "Impact of Diabetes on ACE/ACE2 Balance and Angiotensin II Type 1 Receptor Expression in db/db Diabetic Mice" @default.
- W634603280 cites W147553750 @default.
- W634603280 cites W1512068992 @default.
- W634603280 cites W1607247614 @default.
- W634603280 cites W1819973517 @default.
- W634603280 cites W1849649569 @default.
- W634603280 cites W1897861630 @default.
- W634603280 cites W1964696346 @default.
- W634603280 cites W1965166514 @default.
- W634603280 cites W1965894638 @default.
- W634603280 cites W1970709580 @default.
- W634603280 cites W1972329582 @default.
- W634603280 cites W1973716434 @default.
- W634603280 cites W1974548284 @default.
- W634603280 cites W1975073519 @default.
- W634603280 cites W1975155462 @default.
- W634603280 cites W1978387124 @default.
- W634603280 cites W1978468783 @default.
- W634603280 cites W1978998472 @default.
- W634603280 cites W1980295850 @default.
- W634603280 cites W1981060500 @default.
- W634603280 cites W1985085733 @default.
- W634603280 cites W1986081091 @default.
- W634603280 cites W1988170133 @default.
- W634603280 cites W1989224608 @default.
- W634603280 cites W1990941703 @default.
- W634603280 cites W1991926280 @default.
- W634603280 cites W1992716613 @default.
- W634603280 cites W1992737191 @default.
- W634603280 cites W1993110263 @default.
- W634603280 cites W1994421856 @default.
- W634603280 cites W1994885783 @default.
- W634603280 cites W1995203528 @default.
- W634603280 cites W1998432167 @default.
- W634603280 cites W2000040025 @default.
- W634603280 cites W2001212657 @default.
- W634603280 cites W2004164169 @default.
- W634603280 cites W2009802653 @default.
- W634603280 cites W2012531860 @default.
- W634603280 cites W2012768966 @default.
- W634603280 cites W2013987899 @default.
- W634603280 cites W2015111258 @default.
- W634603280 cites W2017524002 @default.
- W634603280 cites W2018254791 @default.
- W634603280 cites W2019767570 @default.
- W634603280 cites W2020267609 @default.
- W634603280 cites W2020554424 @default.
- W634603280 cites W2020571025 @default.
- W634603280 cites W2022841004 @default.
- W634603280 cites W2023531846 @default.
- W634603280 cites W2025672718 @default.
- W634603280 cites W2026437193 @default.
- W634603280 cites W2028439883 @default.
- W634603280 cites W2028507800 @default.
- W634603280 cites W2028521865 @default.
- W634603280 cites W2028626467 @default.
- W634603280 cites W2032037180 @default.
- W634603280 cites W2035875362 @default.
- W634603280 cites W2041334028 @default.
- W634603280 cites W2043623132 @default.
- W634603280 cites W2043721542 @default.
- W634603280 cites W2046159055 @default.
- W634603280 cites W2051159435 @default.
- W634603280 cites W2056976690 @default.
- W634603280 cites W2057105818 @default.
- W634603280 cites W2058549187 @default.
- W634603280 cites W2058838828 @default.
- W634603280 cites W2060204625 @default.
- W634603280 cites W2060462859 @default.
- W634603280 cites W2063597031 @default.
- W634603280 cites W2066971442 @default.
- W634603280 cites W2075052319 @default.
- W634603280 cites W2078751569 @default.
- W634603280 cites W2090895117 @default.
- W634603280 cites W2092532993 @default.
- W634603280 cites W2093583963 @default.
- W634603280 cites W2094858676 @default.
- W634603280 cites W2097288698 @default.
- W634603280 cites W2098154750 @default.
- W634603280 cites W2099131776 @default.
- W634603280 cites W2100558876 @default.
- W634603280 cites W2101610495 @default.
- W634603280 cites W2102235083 @default.
- W634603280 cites W2104103470 @default.
- W634603280 cites W2104899725 @default.
- W634603280 cites W2104916280 @default.
- W634603280 cites W2104943661 @default.
- W634603280 cites W2106281270 @default.
- W634603280 cites W2107709584 @default.
- W634603280 cites W2108702111 @default.
- W634603280 cites W2109258405 @default.
- W634603280 cites W2109850544 @default.
- W634603280 cites W2111190158 @default.
- W634603280 cites W2111780029 @default.
- W634603280 cites W2112894886 @default.