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- W63477079 abstract "Theileria parva is an obligate, intracellular, parasitic protozoan that causes East Coast fever, an acute leukemia-like disease of cattle. T. parva and the related parasite, Theileria annulata, are unique among protozoa in that their intralymphocytic stages induce transformation of bovid lymphocytes. Comparison of in vitro protein kinase activities between uninfected IL-2-dependent T lymphoblasts and T. parva-infected lymphocytes revealed a 4.7- to 12-fold increase in total phosphorylation and the induction of a group of Theileria infection-specific phosphoproteins. The enzyme that phosphorylates these substrates is a serine/threonine kinase with substrate and effector specificities of casein kinase (CK) II. Northern blot analyses revealed a 3.9- to 6.0-fold increase in CKII alpha mRNA in the infected cells relative to the controls. Furthermore, a marked increase of CKII antigen was observed on Western blots of materials prepared from the infected cell lines. The antibovine CKII antibody used in these studies immunoprecipitated a protein kinase that phosphorylated casein in a reaction that was inhibited by low (nM) quantities of heparin. Our data show marked increases of bovine CKII at the transcriptional, translational and functional levels in T. parva-infected lymphocytes, relative to quiescent cells or IL-2-dependent parental lymphoblasts. Bovine CKII thus appears to be constitutively activated in these cells and we propose that this kinase may be an important element in the signal-transducing pathways activated by Theileria in bovid lymphocytes and perhaps in some leukemic cells." @default.
- W63477079 created "2016-06-24" @default.
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- W63477079 creator A5042491943 @default.
- W63477079 creator A5076615282 @default.
- W63477079 date "1993-04-01" @default.
- W63477079 modified "2023-10-10" @default.
- W63477079 title "Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva." @default.
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- W63477079 doi "https://doi.org/10.1002/j.1460-2075.1993.tb05807.x" @default.
- W63477079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413376" @default.
- W63477079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8467809" @default.
- W63477079 hasPublicationYear "1993" @default.
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