Matches in SemOpenAlex for { <https://semopenalex.org/work/W635070110> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W635070110 abstract "The primary objective of this research project was to identify prostate cancer (PCa) -specific biomarkers from urine. This was done using a multi-faceted approach that targeted (1) the genome (DNA); (2) the transcriptome (mRNA and miRNA); and (3) the proteome. Toward this end, urine samples were collected from ten healthy individuals, eight men with PCa and twelve men with enlarged, non-cancerous prostates or with Benign Prostatic Hyperplasia (BPH). Urine samples were also collected from the same patients (PCa and BPH) as part of a two-year follow-up.Initially urinary nucleic acids and proteins were assessed both qualitatively and quantitatively for characteristics either unique or common among the groups. Subsequently macromolecules were pooled within each group and assessed for either protein composition via LC-MS/MS or microRNA (miRNA) expression by microarray. A number of potential candidates including miRNAs were identified as being deregulated in either pooled PCa or BPH with respect to the healthy control group.Candidate biomarkers were then assessed among individual samples to validate their utility in diagnosing PCa and/or differentiating PCa from BPH. A number of potential targets including deregulation of miRNAs 1825 and 484, and mRNAs for Fibronectin and Tumor Protein 53 Inducible Nuclear Protein 2 (TP53INP2) appeared to be indicative of PCa. Furthermore, deregulation of miR-498 appeared to be indicative of BPH. The sensitivities and specificities associated with using deregulation in many of these targets to subsequently predict PCa or BPH were also determined.This research project has identified a number of potential targets, detectable in urine, which merit further investigation towards the accurate identification of PCa and its discrimination from BPH. The significance of this work is amplified by the non-invasive nature of the sample source from which these candidates were derived, urine. Many cancer biomarker discovery studies have tended to focus primarily on blood (plasma or serum) and/or tissue samples. This is one of the first PCa biomarker studies to focus exclusively on urine as a sample source." @default.
- W635070110 created "2016-06-24" @default.
- W635070110 creator A5002522667 @default.
- W635070110 date "2013-05-06" @default.
- W635070110 modified "2023-09-27" @default.
- W635070110 title "Prostate Cancer and the Search for Novel Biomarkers" @default.
- W635070110 hasPublicationYear "2013" @default.
- W635070110 type Work @default.
- W635070110 sameAs 635070110 @default.
- W635070110 citedByCount "0" @default.
- W635070110 crossrefType "dissertation" @default.
- W635070110 hasAuthorship W635070110A5002522667 @default.
- W635070110 hasConcept C104317684 @default.
- W635070110 hasConcept C104397665 @default.
- W635070110 hasConcept C121608353 @default.
- W635070110 hasConcept C126322002 @default.
- W635070110 hasConcept C145059251 @default.
- W635070110 hasConcept C150194340 @default.
- W635070110 hasConcept C162317418 @default.
- W635070110 hasConcept C186836561 @default.
- W635070110 hasConcept C24107716 @default.
- W635070110 hasConcept C2777562237 @default.
- W635070110 hasConcept C2780026642 @default.
- W635070110 hasConcept C2780192828 @default.
- W635070110 hasConcept C54355233 @default.
- W635070110 hasConcept C60644358 @default.
- W635070110 hasConcept C70721500 @default.
- W635070110 hasConcept C71924100 @default.
- W635070110 hasConcept C86803240 @default.
- W635070110 hasConceptScore W635070110C104317684 @default.
- W635070110 hasConceptScore W635070110C104397665 @default.
- W635070110 hasConceptScore W635070110C121608353 @default.
- W635070110 hasConceptScore W635070110C126322002 @default.
- W635070110 hasConceptScore W635070110C145059251 @default.
- W635070110 hasConceptScore W635070110C150194340 @default.
- W635070110 hasConceptScore W635070110C162317418 @default.
- W635070110 hasConceptScore W635070110C186836561 @default.
- W635070110 hasConceptScore W635070110C24107716 @default.
- W635070110 hasConceptScore W635070110C2777562237 @default.
- W635070110 hasConceptScore W635070110C2780026642 @default.
- W635070110 hasConceptScore W635070110C2780192828 @default.
- W635070110 hasConceptScore W635070110C54355233 @default.
- W635070110 hasConceptScore W635070110C60644358 @default.
- W635070110 hasConceptScore W635070110C70721500 @default.
- W635070110 hasConceptScore W635070110C71924100 @default.
- W635070110 hasConceptScore W635070110C86803240 @default.
- W635070110 hasLocation W6350701101 @default.
- W635070110 hasOpenAccess W635070110 @default.
- W635070110 hasPrimaryLocation W6350701101 @default.
- W635070110 hasRelatedWork W1967614819 @default.
- W635070110 hasRelatedWork W1969270395 @default.
- W635070110 hasRelatedWork W2045807095 @default.
- W635070110 hasRelatedWork W2058183149 @default.
- W635070110 hasRelatedWork W2118786830 @default.
- W635070110 hasRelatedWork W2137251077 @default.
- W635070110 hasRelatedWork W2267059343 @default.
- W635070110 hasRelatedWork W2500746494 @default.
- W635070110 hasRelatedWork W2589111289 @default.
- W635070110 hasRelatedWork W2897574108 @default.
- W635070110 hasRelatedWork W2945138039 @default.
- W635070110 hasRelatedWork W2967981110 @default.
- W635070110 hasRelatedWork W3006749919 @default.
- W635070110 hasRelatedWork W3007464454 @default.
- W635070110 hasRelatedWork W3029280971 @default.
- W635070110 hasRelatedWork W3038505198 @default.
- W635070110 hasRelatedWork W3149078382 @default.
- W635070110 hasRelatedWork W3164825570 @default.
- W635070110 hasRelatedWork W3201956859 @default.
- W635070110 hasRelatedWork W3206344332 @default.
- W635070110 isParatext "false" @default.
- W635070110 isRetracted "false" @default.
- W635070110 magId "635070110" @default.
- W635070110 workType "dissertation" @default.