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- W635322510 abstract "Mycobacterium tuberculosis is an obligate human pathogen that is transmitted by aerosol from patients with pulmonary tuberculosis. Until recently, the evolution of tuberculosis remained largely in the realms of speculation. However, the genomics revolution has had the same dramatic effect on the study of M. tuberculosis as it has had on the study of other bacterial pathogens. This chapter has been structured around the different genetic approaches that are providing insights into the evolution of M. tuberculosis and have specifically emphasized important new findings emerging from recent studies of population genetics. A more complete understanding of the evolution of pathogenic mycobacteria will ultimately require definition of the genomic changes that accompanied the transition to a pathogenic lifestyle. One of the most significant genetic observations with relevance to understanding the evolution of M. tuberculosis has been the lack of single nucleotide polymorphisms (SNPs) detected among clinical isolates of M. tuberculosis. Recently, phylogenies based on large sequence polymorphisms (LSPs) or SNPs have confirmed that M. canettii is deeply branched from the other M. tuberculosis complex members. Until recently, however, there was little formal effort to understand M. tuberculosis from an evolutionary perspective. Recent advances in genomics now make it possible to explore the evolution of M. tuberculosis." @default.
- W635322510 created "2016-06-24" @default.
- W635322510 creator A5008730420 @default.
- W635322510 creator A5037832688 @default.
- W635322510 date "2014-04-30" @default.
- W635322510 modified "2023-09-23" @default.
- W635322510 title "Mycobacterial Evolution: Insights from Genomics and Population Genetics" @default.
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