Matches in SemOpenAlex for { <https://semopenalex.org/work/W63554784> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W63554784 abstract "The inhibition of glycolysis by H{sub 2}O{sub 2} has been attributed to oxidative inactivation of glyceraldehyde-3-phosphate dehydrogenase (G3PDH). The authors previous work using isolated, intact rat retinas suggested that the inter-action between H{sub 2}O{sub 2} and pyruvate could also contribute to the decrease in glycolysis, though G3PDH was not measured. The strategy of the present work was to compare the effects of H{sub 2}O{sub 2} with those of iodoacetate (IAA), which inactivates G3PDH but does not interact with pyruvate, on glycolysis of retinas and on the activity of G3PDH, as measured in post-incubation supernatant fractions of these retinas. When the enzyme activity was inhibited by 50% with 0.01 mM IAA, the glycolytic rate was not significantly different from the control value. However, when H{sub 2}O{sub 2} produced a 50% inhibition of the enzyme the glycolytic rate was decreased by 70% relative to the control tissue. With 0.1 mM H{sub 2}O{sub 2}, the enzyme inhibition was about 15% but the lactate produced declined by about 20%. Glycolysis was suppressed completely when the enzyme was inhibited by 99+% with either H{sub 2}O{sub 2} or IAA. Though G3PDH is clearly inhibited by H{sub 2}O{sub 2}, it appears that this inhibition alone may notmore » account for the decline in glycolysis.« less" @default.
- W63554784 created "2016-06-24" @default.
- W63554784 creator A5050132494 @default.
- W63554784 creator A5075278417 @default.
- W63554784 date "1990-02-26" @default.
- W63554784 modified "2023-09-23" @default.
- W63554784 title "Inhibition of glycolysis by H sub 2 O sub 2 is not due to inhibition of G3PDH" @default.
- W63554784 hasPublicationYear "1990" @default.
- W63554784 type Work @default.
- W63554784 sameAs 63554784 @default.
- W63554784 citedByCount "0" @default.
- W63554784 crossrefType "journal-article" @default.
- W63554784 hasAuthorship W63554784A5050132494 @default.
- W63554784 hasAuthorship W63554784A5075278417 @default.
- W63554784 hasConcept C126322002 @default.
- W63554784 hasConcept C134792803 @default.
- W63554784 hasConcept C181199279 @default.
- W63554784 hasConcept C185592680 @default.
- W63554784 hasConcept C20251656 @default.
- W63554784 hasConcept C25642318 @default.
- W63554784 hasConcept C2776317432 @default.
- W63554784 hasConcept C2777318727 @default.
- W63554784 hasConcept C55493867 @default.
- W63554784 hasConcept C55885012 @default.
- W63554784 hasConcept C57600042 @default.
- W63554784 hasConcept C71924100 @default.
- W63554784 hasConcept C86803240 @default.
- W63554784 hasConceptScore W63554784C126322002 @default.
- W63554784 hasConceptScore W63554784C134792803 @default.
- W63554784 hasConceptScore W63554784C181199279 @default.
- W63554784 hasConceptScore W63554784C185592680 @default.
- W63554784 hasConceptScore W63554784C20251656 @default.
- W63554784 hasConceptScore W63554784C25642318 @default.
- W63554784 hasConceptScore W63554784C2776317432 @default.
- W63554784 hasConceptScore W63554784C2777318727 @default.
- W63554784 hasConceptScore W63554784C55493867 @default.
- W63554784 hasConceptScore W63554784C55885012 @default.
- W63554784 hasConceptScore W63554784C57600042 @default.
- W63554784 hasConceptScore W63554784C71924100 @default.
- W63554784 hasConceptScore W63554784C86803240 @default.
- W63554784 hasLocation W635547841 @default.
- W63554784 hasOpenAccess W63554784 @default.
- W63554784 hasPrimaryLocation W635547841 @default.
- W63554784 hasRelatedWork W116009408 @default.
- W63554784 hasRelatedWork W1551575020 @default.
- W63554784 hasRelatedWork W1574256091 @default.
- W63554784 hasRelatedWork W1626152187 @default.
- W63554784 hasRelatedWork W188959512 @default.
- W63554784 hasRelatedWork W1973215835 @default.
- W63554784 hasRelatedWork W1994906855 @default.
- W63554784 hasRelatedWork W1995670003 @default.
- W63554784 hasRelatedWork W2012087116 @default.
- W63554784 hasRelatedWork W2016844598 @default.
- W63554784 hasRelatedWork W2053660147 @default.
- W63554784 hasRelatedWork W207043491 @default.
- W63554784 hasRelatedWork W2128012018 @default.
- W63554784 hasRelatedWork W220779535 @default.
- W63554784 hasRelatedWork W2223203646 @default.
- W63554784 hasRelatedWork W239453668 @default.
- W63554784 hasRelatedWork W266999806 @default.
- W63554784 hasRelatedWork W284174124 @default.
- W63554784 hasRelatedWork W332363481 @default.
- W63554784 hasRelatedWork W62010283 @default.
- W63554784 isParatext "false" @default.
- W63554784 isRetracted "false" @default.
- W63554784 magId "63554784" @default.
- W63554784 workType "article" @default.