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- W63612822 abstract "Oxaliplatin, a platinum-based drug that is typically part of the FOLFOX chemotherapy regimen (folinic acid, fluorouracil, and oxaliplatin) used in colorectal cancer, was initially described as a non-vesicant. Subsequent case reports of oxaliplatin extravasation, however, described local tissue inflammation and necrosis, which led to its reclassification as an irritant or a low-risk vesicant.1 In reviewing the literature, we identified 6 published reports describing a total of 16 patients that suffered oxaliplatin extravasation, in addition to 9 patients identified in the preand post-marketing surveillance of oxaliplatin.1-7 All published cases involved extravasation into the subcutaneous tissues of the upper extremities or the breast, either through a peripheral vein (19 cases) or via a central catheter (6 cases). Most patients experienced mild tissue inflammation, with few cases resulting in severe reactions and tissue necrosis. Here, we report a case of accidental oxaliplatin infusion into the mediastinum through a central venous catheter. To our knowledge, no similar cases have been reported in the literature." @default.
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- W63612822 date "2012-08-01" @default.
- W63612822 modified "2023-09-23" @default.
- W63612822 title "Extravasation of oxaliplatin into the mediastinum: a case report and review of the literature." @default.
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