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- W636154926 abstract "目的:探讨HIV-1蛋白酶抑制剂nelfinavir对胰岛β细胞内胰岛素信号传导蛋白磷酸化的影响.方法:体外观察鼠胰岛素瘤INS-1细胞经nelfinavir治疗48 h后,用100 nmol/L胰岛素刺激2 min,细胞裂解产物中的胰岛素信号传导蛋白磷酸化采用免疫沉淀和Western印迹方法测定.用台盼蓝染色细胞计数和MTT衰减试验,评估nelfinavir对INS-1细胞活力的影响.结果:nelfinavir降低胰岛素刺激的胰岛素受体底物IRS-2和Akt-Thr308磷酸化,并呈剂量依赖关系.nelfinavir浓度为10 μmol/L时,分别降低IRS-2和Akt-Thr308磷酸化达52%和55%,在这个浓度下nelfinavir没有细胞毒性作用.结论:nelfinavir治疗可以损害胰岛β细胞内IRS-2介导的信号传导." @default.
- W636154926 created "2016-06-24" @default.
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- W636154926 date "2004-01-01" @default.
- W636154926 modified "2023-09-24" @default.
- W636154926 title "Nelfinavir损害鼠胰岛素瘤INS-1细胞内IRS-2信号传导" @default.
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