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- W636200318 abstract "OBJECTIVE To evaluate the effect of tibolone on mild cognitive impairment in postmenopausal patients, the concentration of malondialdehyde/4- hidroxinonenal and anthropometric parameters. METHODS Twenty menopausal patients (50–55 years old) were included. The determinations were clinical history, body mass index, waist-hip ratio, percentage of body fat, concentration of malondialdehyde/4- hidroxinonenal, and the cognitive function; which were evaluated before and 3 months after of treatment with tibolone. RESULTS Tibolone improved cognitive function in 77% of patients who had mild cognitive impairment baseline. Also reduced damage to lipid marker for oxidative stress (17 vs 11 nM MDA-HNE before and after treatment, respectively), but anthropometric parameters were unchanged. The correlation analysis showed that at low lipid damage is a higher score in memory. CONCLUSIONS Tibolone decreased mild cognitive impairment and the concentration of markers of lipid damage by oxidative stress, but did not reduce body mass index, waist-hip index and fat percentage." @default.
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- W636200318 date "2012-04-01" @default.
- W636200318 modified "2023-09-27" @default.
- W636200318 title "EFFECT OF TIBOLONE ON MILD COGNITIVE IMPAIRMENT IN POSTMENOPAUSAL PATIENTS" @default.
- W636200318 doi "https://doi.org/10.1096/fasebj.26.1_supplement.847.5" @default.
- W636200318 hasPublicationYear "2012" @default.
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