FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W63631696> ?p ?o ?g. }

• W63631696 endingPage "20" @default.
• W63631696 startingPage "1" @default.
• W63631696 abstract "It is well recognized that the oxidant gases ozone and nitrogen dioxide cause lung injury at high concentrations and, as such, are considered to be hazardous air pollutants. What is not known is the upper limit of their concentration in ambient air that can be tolerated without causing lung injury. This uncertainty is due, in major part, to a lack of sensitive and noninvasive tests that can identify the presence of early lung injury after exposure to oxidant gases. The hypothesis underlying the studies reported in this document was that the changes in cell populations that occur in the lung after oxidant lung injury are due to the local generation of lung-cell-specific growth factors, and that these factors should leak into the blood stream in sufficient quantities to allow their identification. Once identified, such factors could be used as early markers of oxidant injury. The question asked in the design of these studies was: Is oxidant lung injury associated with the appearance in blood of factors that enhance lung cell growth, as tested in a cultured lung cell bioassay? Groups of rats were exposed to either 1 ppm ozone, 85 percent oxygen, or air, and samples of plasma, lung washings, and lung tissue were collected at intervals over a two-week period. These samples were tested for their effect on the DNA synthesis of purified populations of three major lung cell types (pneumocyte, fibroblast, and endothelial cell) in culture. The concentrations of the two oxidant gases used in these studies were selected on the basis of their known effect on these cell types in the intact animal. The collected samples were tested either whole or after separation into various fractions, determined by the preference of the sample's constituents for an alkaline or acidic environment. This fractionation procedure was included because simple testing of crude samples may not always reveal the presence of biologically active material because both growth stimulators and growth inhibitors may be present in the same sample. The results from testing whole samples confirm that factors that enhance DNA synthesis by all three lung cell types do appear in blood and lavage after exposure to 1 ppm ozone or 85 percent oxygen. These factors appear to be distinct for each lung cell type, in that the timing of maximal activity in the collected samples differs for each cell type. The time at which they appear in blood bears a close temporal relationship with cellular changes reported to occur in the whole lung of similarly exposed animals.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W63631696 created "2016-06-24" @default.
• W63631696 creator A5023027480 @default.
• W63631696 date "1989-02-01" @default.
• W63631696 modified "2023-09-27" @default.
• W63631696 title "Detection of paracrine factors in oxidant lung injury." @default.
• W63631696 cites W1542431954 @default.
• W63631696 cites W1550447653 @default.
• W63631696 cites W1832032355 @default.
• W63631696 cites W1894641937 @default.
• W63631696 cites W1957734831 @default.
• W63631696 cites W1983041452 @default.
• W63631696 cites W2057729296 @default.
• W63631696 cites W2074057807 @default.
• W63631696 cites W2163466150 @default.
• W63631696 cites W2166859563 @default.
• W63631696 cites W2413831166 @default.
• W63631696 cites W2896359366 @default.
• W63631696 cites W51309640 @default.
• W63631696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2604917" @default.
• W63631696 hasPublicationYear "1989" @default.
• W63631696 type Work @default.
• W63631696 sameAs 63631696 @default.
• W63631696 citedByCount "0" @default.
• W63631696 crossrefType "journal-article" @default.
• W63631696 hasAuthorship W63631696A5023027480 @default.
• W63631696 hasConcept C126322002 @default.
• W63631696 hasConcept C142724271 @default.
• W63631696 hasConcept C1491633281 @default.
• W63631696 hasConcept C16685009 @default.
• W63631696 hasConcept C170493617 @default.
• W63631696 hasConcept C178790620 @default.
• W63631696 hasConcept C185592680 @default.
• W63631696 hasConcept C2777714996 @default.
• W63631696 hasConcept C2780723490 @default.
• W63631696 hasConcept C508106653 @default.
• W63631696 hasConcept C55493867 @default.
• W63631696 hasConcept C71924100 @default.
• W63631696 hasConcept C7876069 @default.
• W63631696 hasConcept C86803240 @default.
• W63631696 hasConcept C98274493 @default.
• W63631696 hasConceptScore W63631696C126322002 @default.
• W63631696 hasConceptScore W63631696C142724271 @default.
• W63631696 hasConceptScore W63631696C1491633281 @default.
• W63631696 hasConceptScore W63631696C16685009 @default.
• W63631696 hasConceptScore W63631696C170493617 @default.
• W63631696 hasConceptScore W63631696C178790620 @default.
• W63631696 hasConceptScore W63631696C185592680 @default.
• W63631696 hasConceptScore W63631696C2777714996 @default.
• W63631696 hasConceptScore W63631696C2780723490 @default.
• W63631696 hasConceptScore W63631696C508106653 @default.
• W63631696 hasConceptScore W63631696C55493867 @default.
• W63631696 hasConceptScore W63631696C71924100 @default.
• W63631696 hasConceptScore W63631696C7876069 @default.
• W63631696 hasConceptScore W63631696C86803240 @default.
• W63631696 hasConceptScore W63631696C98274493 @default.
• W63631696 hasIssue "22" @default.
• W63631696 hasLocation W636316961 @default.
• W63631696 hasOpenAccess W63631696 @default.
• W63631696 hasPrimaryLocation W636316961 @default.
• W63631696 hasRelatedWork W1435961633 @default.
• W63631696 hasRelatedWork W1480521789 @default.
• W63631696 hasRelatedWork W1973757213 @default.
• W63631696 hasRelatedWork W1988328092 @default.
• W63631696 hasRelatedWork W2005670578 @default.
• W63631696 hasRelatedWork W2008600703 @default.
• W63631696 hasRelatedWork W2043736132 @default.
• W63631696 hasRelatedWork W2054061234 @default.
• W63631696 hasRelatedWork W2060861348 @default.
• W63631696 hasRelatedWork W2067745368 @default.
• W63631696 hasRelatedWork W2081770436 @default.
• W63631696 hasRelatedWork W2082847081 @default.
• W63631696 hasRelatedWork W2151985830 @default.
• W63631696 hasRelatedWork W2278015929 @default.
• W63631696 hasRelatedWork W2365283754 @default.
• W63631696 hasRelatedWork W2405701538 @default.
• W63631696 hasRelatedWork W2740887814 @default.
• W63631696 hasRelatedWork W2789744560 @default.
• W63631696 hasRelatedWork W3112638854 @default.
• W63631696 hasRelatedWork W192302164 @default.
• W63631696 hasVolume "22" @default.
• W63631696 isParatext "false" @default.
• W63631696 isRetracted "false" @default.
• W63631696 magId "63631696" @default.
• W63631696 workType "article" @default.