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- W63674154 abstract "Publisher Summary This chapter discusses a study analyzing action of apamin on nerve-muscle transmission and the effects of ATP and noradrenaline in smooth muscles. The first results of this study showed that apamin in concentrations 5 × 10 −9 –5 × 10 −7 M evokes a decrease in the amplitude of the nonadrenergic inhibitory junction potentials (IJP) in smooth muscle cells of the atropinized muscle strip of caecum (taenia coli and circular muscle) of the guinea-pig. By apamin in concentration of 5 ×10 −7 M the nonadrenergic IJPs were completely blocked during 3–5 min after application. However, under these conditions smooth muscle cells of caecum, in response to single-shock intramural stimulation, generated noncholinergic excitatory junction potentials (EJP) instead of IJPs. Apamin during the first two minutes caused not only a decrease in the IJP amplitude, but also produced a considerable increase in its latency. Subsequently, a small synaptic depolarizing wave appeared, the latency of the synaptic response shortened and the IJP amplitude was reduced. Finally, 5 min after apamin application only the EJP followed by a small after-hyperpolarization appeared in response to intramural stimulation." @default.
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- W63674154 date "1981-01-01" @default.
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- W63674154 title "ACTION OF APAMIN ON NERVE-MUSCLE TRANSMISSION AND THE EFFECTS OF ATP AND NORADRENALINE IN SMOOTH MUSCLES" @default.
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- W63674154 doi "https://doi.org/10.1016/b978-0-08-026817-0.50019-6" @default.
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