FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W637616566> ?p ?o ?g. }

• W637616566 abstract "A percutaneous respiratory assist catheter is being developed to partially support native lung function in patients with acute respiratory distress syndrome (ARDS) and acute exacerbations of chronic obstructive pulmonary disease (COPD). Current clinical therapies include pharmacotherapy, mechanical ventilation, and ECLS, but are associated with high mortality rates. The catheter is intended for insertion through the femoral vein for placement in the vena cava where it actively processes venous blood. The artificial lung device consists of a hollow fiber membrane (HFM) bundle that supplements oxygenation and carbon dioxide removal through diffusional processes.The catheter is a second generation concept of the Hattler Catheter with a design goal of size reduction to accommodate percutaneous insertion. The tradeoff in available HFM surface area requires the catheter to be more efficient in removing CO2 per unit surface area. Two prototypes utilizing rotational mechanisms to actively mix the blood and reduce mass transfer boundary layers were evaluated. The first prototype consisted of a rotating HFM bundle capable of rates of 10,000 RPM but required a structure for vessel wall protection. The second prototype employed a rotating impeller within a stationary HFM bundle to internalize rotational components within the device. The prototypes were evaluated in vitro and in vivo to assess design and performance. Development of impeller geometries, a saline seal purge, and device flexibility were notable design highlights. Acceptable hemolysis levels were observed in testing the concept of using a high-speed rotational HFM bundle. Standard gas exchange characterization tests in DI water showed over a two-fold increase in CO2 removal efficiency of 450 and 529 ml CO2/min/m2, rotational catheter and impeller catheter respectively, over the Hattler Catheter. The impeller catheter was evaluated in a bovine model and an average efficiency of 513 ± 20 ml CO2/min/m2 was attained at 20,000 RPM. Catheter size reduction and CO2 removal efficiency enhancements were successfully achieved. A separate novel method to augment CO2 concentration gradients is being researched to integrate with HFMs and attain overall gas exchange project goals." @default.
• W637616566 created "2016-06-24" @default.
• W637616566 creator A5021373583 @default.
• W637616566 date "2007-09-25" @default.
• W637616566 modified "2023-09-27" @default.
• W637616566 title "EVALUATION OF ROTATIONAL MECHANISMS TO ENHANCE PERFORMANCE OF A RESPIRATORY ASSIST CATHETER" @default.
• W637616566 cites W105869727 @default.
• W637616566 cites W12184236 @default.
• W637616566 cites W1535451833 @default.
• W637616566 cites W1559476703 @default.
• W637616566 cites W1591500609 @default.
• W637616566 cites W1971189120 @default.
• W637616566 cites W1978073801 @default.
• W637616566 cites W1980132648 @default.
• W637616566 cites W1990449163 @default.
• W637616566 cites W1992723329 @default.
• W637616566 cites W1996159474 @default.
• W637616566 cites W2003314888 @default.
• W637616566 cites W2003566862 @default.
• W637616566 cites W2009767777 @default.
• W637616566 cites W2011478035 @default.
• W637616566 cites W2013191904 @default.
• W637616566 cites W2013546209 @default.
• W637616566 cites W2021554464 @default.
• W637616566 cites W2028342286 @default.
• W637616566 cites W2032979792 @default.
• W637616566 cites W2033446731 @default.
• W637616566 cites W2034772382 @default.
• W637616566 cites W2035226813 @default.
• W637616566 cites W2035579010 @default.
• W637616566 cites W2045295156 @default.
• W637616566 cites W2050396591 @default.
• W637616566 cites W2050735468 @default.
• W637616566 cites W2060665379 @default.
• W637616566 cites W2066577620 @default.
• W637616566 cites W2069196776 @default.
• W637616566 cites W2075579374 @default.
• W637616566 cites W2082859812 @default.
• W637616566 cites W2084599457 @default.
• W637616566 cites W2087486842 @default.
• W637616566 cites W2087604391 @default.
• W637616566 cites W2115389261 @default.
• W637616566 cites W2122945432 @default.
• W637616566 cites W2126219348 @default.
• W637616566 cites W2142050005 @default.
• W637616566 cites W2161328469 @default.
• W637616566 cites W2165144866 @default.
• W637616566 cites W2302666774 @default.
• W637616566 cites W2315166547 @default.
• W637616566 cites W2403535541 @default.
• W637616566 cites W2418168333 @default.
• W637616566 cites W2426057769 @default.
• W637616566 cites W2597070792 @default.
• W637616566 cites W1763654671 @default.
• W637616566 cites W1970164609 @default.
• W637616566 cites W2118191353 @default.
• W637616566 hasPublicationYear "2007" @default.
• W637616566 type Work @default.
• W637616566 sameAs 637616566 @default.
• W637616566 citedByCount "0" @default.
• W637616566 crossrefType "journal-article" @default.
• W637616566 hasAuthorship W637616566A5021373583 @default.
• W637616566 hasConcept C126322002 @default.
• W637616566 hasConcept C127413603 @default.
• W637616566 hasConcept C136229726 @default.
• W637616566 hasConcept C141071460 @default.
• W637616566 hasConcept C153005164 @default.
• W637616566 hasConcept C192562407 @default.
• W637616566 hasConcept C2776348555 @default.
• W637616566 hasConcept C2777714996 @default.
• W637616566 hasConcept C2780813298 @default.
• W637616566 hasConcept C2781267111 @default.
• W637616566 hasConcept C42219234 @default.
• W637616566 hasConcept C71924100 @default.
• W637616566 hasConcept C78519656 @default.
• W637616566 hasConceptScore W637616566C126322002 @default.
• W637616566 hasConceptScore W637616566C127413603 @default.
• W637616566 hasConceptScore W637616566C136229726 @default.
• W637616566 hasConceptScore W637616566C141071460 @default.
• W637616566 hasConceptScore W637616566C153005164 @default.
• W637616566 hasConceptScore W637616566C192562407 @default.
• W637616566 hasConceptScore W637616566C2776348555 @default.
• W637616566 hasConceptScore W637616566C2777714996 @default.
• W637616566 hasConceptScore W637616566C2780813298 @default.
• W637616566 hasConceptScore W637616566C2781267111 @default.
• W637616566 hasConceptScore W637616566C42219234 @default.
• W637616566 hasConceptScore W637616566C71924100 @default.
• W637616566 hasConceptScore W637616566C78519656 @default.
• W637616566 hasLocation W6376165661 @default.
• W637616566 hasOpenAccess W637616566 @default.
• W637616566 hasPrimaryLocation W6376165661 @default.
• W637616566 hasRelatedWork W1558317225 @default.
• W637616566 hasRelatedWork W1915663109 @default.
• W637616566 hasRelatedWork W1976861951 @default.
• W637616566 hasRelatedWork W1979817445 @default.
• W637616566 hasRelatedWork W2001952600 @default.
• W637616566 hasRelatedWork W2003566862 @default.
• W637616566 hasRelatedWork W2010971947 @default.
• W637616566 hasRelatedWork W2024164343 @default.
• W637616566 hasRelatedWork W2031588852 @default.

• next