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- W637658568 abstract "The mouse dilute-neurological (d-n) is a new spontaneous mutation in myosin Va that functions as an actin-based molecular motor. The cerebella of d-n mice were examined by light and electron microscopy at 19 days of age when the mice exhibited a neurological disorder characterized by ataxia and opisthotonus in addition to a lightened coat color and at 40 days when they were free of neurological disorder. Purkinje cells appeared normal at both 19 and 40 days of age by light microscopy. In electron microscopy, smooth endoplasmic reticulum (SER) was absent in the dendritic spine of Purkinje cells at 19 days of age but was present in some spines at 40 days. The neurological phenotype of d-n mice may be attributed in part to a failure of SER transport into the spine of Purkinje cells at a younger age and to an accumulation of SER in the spine in older d-n mice." @default.
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- W637658568 date "2001-12-01" @default.
- W637658568 modified "2023-09-24" @default.
- W637658568 title "Electron microscopic observation of smooth endoplasmic reticulum in the dendritic spine of Purkinje cells in dilute-neurological mice" @default.
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